Mus musculus

1. M2-KC-FEV activates JAK–STAT signalling in mouse cells.

   Cells

   Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging · ACS applied materials & interfaces · 1 Oct 2026

2. M2-KC-FEV decreases reactive oxygen species in mouse cells.

   Cellsin UVB-injured mouse keratinocytes and dermal fibroblasts

   Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging · ACS applied materials & interfaces · 1 Oct 2026

3. M2-KC-FEV protects against skin photoaging in mice.

   AnimalsUVB-challengedskin

   Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging · ACS applied materials & interfaces · 1 Oct 2026

4. M2-KC-FEV decreases cellular senescence in mouse cells.

   Cellsin UVB-injured mouse keratinocytes and dermal fibroblasts

   Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging · ACS applied materials & interfaces · 1 Oct 2026

M2-KC-FEV →

1. Icariin inhibits NLRP3 inflammasome in mice.

   Animals

   Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice · Chinese journal of natural medicines · 1 Oct 2026

2. Icariin decreases mitochondrial reactive oxygen species in mice.

   Animals

   Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice · Chinese journal of natural medicines · 1 Oct 2026

3. Icariin activates mitophagy in mice.

   Animals

   Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice · Chinese journal of natural medicines · 1 Oct 2026

4. Icariin decreases cognitive deficits in mice.

   Animalsin APP/PS1 mice

   Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice · Chinese journal of natural medicines · 1 Oct 2026

Icariin →

1. Camellia sinensis inhibits NF-κB signalling in mice.

   Animalsin D-galactose-induced agingNongxiang-type Tieguanyin extractliver110 or 550 mg/kg/day8 weeks

   Protective Effects of Nongxiang-Type Tieguanyin on the Liver of D-Galactose-Induced Aging C57BL/6 Mice via the NF-κB Signaling Pathway · Food science & nutrition · 29 Sep 2026

2. Camellia sinensis decreases liver fibrosis in mice.

   Animalsin D-galactose-induced agingNongxiang-type Tieguanyin extractliver110 or 550 mg/kg/day8 weeks

   Protective Effects of Nongxiang-Type Tieguanyin on the Liver of D-Galactose-Induced Aging C57BL/6 Mice via the NF-κB Signaling Pathway · Food science & nutrition · 29 Sep 2026

3. Camellia sinensis decreases cellular senescence in mice.

   Animalsin D-galactose-induced agingNongxiang-type Tieguanyin extractliver110 or 550 mg/kg/day8 weeks

   Protective Effects of Nongxiang-Type Tieguanyin on the Liver of D-Galactose-Induced Aging C57BL/6 Mice via the NF-κB Signaling Pathway · Food science & nutrition · 29 Sep 2026

4. Camellia sinensis improves exercise endurance in mice.

   Animalsin D-galactose-induced agingNongxiang-type Tieguanyin extract110 or 550 mg/kg/day8 weeks

   Protective Effects of Nongxiang-Type Tieguanyin on the Liver of D-Galactose-Induced Aging C57BL/6 Mice via the NF-κB Signaling Pathway · Food science & nutrition · 29 Sep 2026

Camellia sinensis →

1. Astrocyte-conditioned solution decreases pro-inflammatory cytokines in mice.

   Animals

   Astrocytic secretome enhances hippocampal neurogenesis and spatial memory in mice · bioRxiv · 29 Sep 2026 · Preprint

2. Astrocyte-conditioned solution improves spatial memory in mice.

   Animalsin APP/PS1 mice

   Astrocytic secretome enhances hippocampal neurogenesis and spatial memory in mice · bioRxiv · 29 Sep 2026 · Preprint

3. Astrocyte-conditioned solution improves cognitive function in mice.

   Animalsin THY-Tau22 mice

   Astrocytic secretome enhances hippocampal neurogenesis and spatial memory in mice · bioRxiv · 29 Sep 2026 · Preprint

4. Astrocyte-conditioned solution increases adult hippocampal neurogenesis in mice.

   Animalsin young and aged wild-type micehippocampus

   Astrocytic secretome enhances hippocampal neurogenesis and spatial memory in mice · bioRxiv · 29 Sep 2026 · Preprint

Astrocyte-conditioned solution →

1. Photobiomodulation increases Tinf2 in mice.

   Animalszymosan-induced arthritis at 72 h in high-fluence grouplow-power infrared laser (830 nm)joint30 J/cm 272 h

   Low-power infrared laser on telomere maintenance in an experimental model of arthritis · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 29 Sep 2026

2. Photobiomodulation increases Pot1a in mice.

   Animalszymosan-induced arthritis at 72 h in high-fluence grouplow-power infrared laser (830 nm)joint30 J/cm 272 h

   Low-power infrared laser on telomere maintenance in an experimental model of arthritis · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 29 Sep 2026

3. Photobiomodulation increases Terf2 in mice.

   Animalszymosan-induced arthritis at 72 h in high-fluence grouplow-power infrared laser (830 nm)joint30 J/cm 272 h

   Low-power infrared laser on telomere maintenance in an experimental model of arthritis · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 29 Sep 2026

4. Photobiomodulation decreases telomerase and telomere maintenance in mice.

   Animalszymosan-induced arthritis at 24 and 48 hlow-power infrared laser (830 nm)joint24-48 h

   Low-power infrared laser on telomere maintenance in an experimental model of arthritis · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 29 Sep 2026

Photobiomodulation →

1. Ghrelin decreases Shbg in mouse cells.

   “Sex hormone-binding globulin (SHBG) showed mainly cytoplasmic localization, was identified as a potential mediator of ghrelin signaling in microglia, and its expression was downregulated following ghrelin treatment.”

   Cellsmicroglia

   Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026

2. Ghrelin decreases chronic inflammation in mice.

   “Ghrelin treatment improved cognitive function, attenuated microglial senescence, and suppressed inflammation”

   Animals

   Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026

3. Ghrelin decreases cellular senescence in mice.

   “Ghrelin treatment improved cognitive function, attenuated microglial senescence, and suppressed inflammation”

   Animalsmicroglia

   Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026

4. Ghrelin improves cognitive function in mice.

   “Ghrelin treatment improved cognitive function, attenuated microglial senescence, and suppressed inflammation”

   Animals

   Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026

Ghrelin →

1. Panax ginseng + schisandra chinensis increases short-chain fatty acids in mice.

   Animalsco-decoctionfeces

   Ginseng-Schisandra ameliorates D-galactose-induced cognitive impairment in mice: Evidence from gut microbiota and metabolomic analyses · Fitoterapia · 28 Sep 2026

2. Panax ginseng + schisandra chinensis decreases malondialdehyde in mice.

   Animalscompared with model miceco-decoction

   Ginseng-Schisandra ameliorates D-galactose-induced cognitive impairment in mice: Evidence from gut microbiota and metabolomic analyses · Fitoterapia · 28 Sep 2026

3. Panax ginseng + schisandra chinensis increases superoxide dismutase in mice.

   Animalscompared with model miceco-decoction

   Ginseng-Schisandra ameliorates D-galactose-induced cognitive impairment in mice: Evidence from gut microbiota and metabolomic analyses · Fitoterapia · 28 Sep 2026

4. Panax ginseng + schisandra chinensis improves cognitive function in mice.

   AnimalsD-galactose-treated mouse modelco-decoction

   Ginseng-Schisandra ameliorates D-galactose-induced cognitive impairment in mice: Evidence from gut microbiota and metabolomic analyses · Fitoterapia · 28 Sep 2026

Panax ginseng + schisandra chinensis →

1. Astragaloside iv protects against mitochondrial dysfunction in mouse cells.

   Cellscardiomyocyte

   Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 28 Sep 2026

2. Astragaloside iv decreases cellular senescence in mice.

   Animalsheart

   Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 28 Sep 2026

3. Astragaloside iv decreases myocardial fibrosis in mice.

   Animalsaging-inducedheart

   Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 28 Sep 2026

4. Astragaloside iv decreases cardiac dysfunction in mice.

   Animalsaging-inducedheart

   Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 28 Sep 2026

Astragaloside iv →

1. Whey protein decreases Fbxo32 in mice.

   “suppression of the muscle atrophy factors MuRF-1 and Atrogin-1 in the ubiquitin-proteasome system via PWPI@MPNs/HA.”

   Animalsin a murine sarcopenia modelPWPI@MPNs/HAskeletal muscle

   Encapsulated sustained-release whey protein improves muscle mass and strength in sarcopenic mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

2. Whey protein decreases Trim63 in mice.

   “suppression of the muscle atrophy factors MuRF-1 and Atrogin-1 in the ubiquitin-proteasome system via PWPI@MPNs/HA.”

   Animalsin a murine sarcopenia modelPWPI@MPNs/HAskeletal muscle

   Encapsulated sustained-release whey protein improves muscle mass and strength in sarcopenic mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

3. Whey protein improves grip strength in mice.

   “PWPI@MPNs25/HA significantly improves lean body content, grip strength, grid hanging time, exhaustion time, and exhaustion distance.”

   Animalsin a murine sarcopenia modelPWPI@MPNs25/HA

   Encapsulated sustained-release whey protein improves muscle mass and strength in sarcopenic mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

4. Whey protein improves lean body mass in mice.

   “In a murine sarcopenia model, PWPI@MPNs25/HA significantly improves lean body content, grip strength, grid hanging time, exhaustion time, and exhaustion distance.”

   Animalsin a murine sarcopenia modelPWPI@MPNs25/HA

   Encapsulated sustained-release whey protein improves muscle mass and strength in sarcopenic mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

Whey protein →

1. Huntingtin aggregate-responsive autophagy gene circuit extends lifespan in mice.

   “This closed-loop intervention improves motor function and extends lifespan.”

   Animalsin R6/2 HD mouse modelplasmid encapsulated in CD98-targeted immunoliposomes

   Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

2. Huntingtin aggregate-responsive autophagy gene circuit improves motor function in mice.

   “This closed-loop intervention improves motor function and extends lifespan.”

   Animalsin R6/2 HD mouse modelplasmid encapsulated in CD98-targeted immunoliposomes

   Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

3. Huntingtin aggregate-responsive autophagy gene circuit decreases chronic inflammation in mice.

   “In the R6/2 HD mouse model, ARAA treatment significantly reduces mHTT burden, attenuates neuroinflammation, and rescues synaptic deficits.”

   Animalsin R6/2 HD mouse modelplasmid encapsulated in CD98-targeted immunoliposomes

   Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

4. Huntingtin aggregate-responsive autophagy gene circuit decreases mutant huntingtin in mice.

   “In the R6/2 HD mouse model, ARAA treatment significantly reduces mHTT burden, attenuates neuroinflammation, and rescues synaptic deficits.”

   Animalsin R6/2 HD mouse modelplasmid encapsulated in CD98-targeted immunoliposomes

   Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

Huntingtin aggregate-responsive autophagy gene circuit →

1. Ghr knockout induces hepatic steatosis in mice.

   “Elevated circulating GH following hepatocyte-specific GHR ablation mediates adipose-liver crosstalk that promotes adipose lipolysis and CD36-dependent hepatic steatosis.”

   Animalshepatocyte-specifichepatocyte-specific knockoutliver

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

2. Ghr knockout impairs cognitive function in mice.

   “reduced metabolic stress resilience, cognitive decline, impaired bone mineralization, and exacerbated inflammaging.”

   Animalshepatocyte-specifichepatocyte-specific knockout

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

3. Ghr knockout increases cellular senescence in mice.

   “hepatocyte-specific GHR knockout mice display accelerated aging-related phenotypes, characterized by shortened lifespan, enhanced cellular senescence”

   Animalshepatocyte-specifichepatocyte-specific knockoutliver

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

4. Ghr knockout shortens lifespan in mice.

   “hepatocyte-specific GHR knockout mice display accelerated aging-related phenotypes, characterized by shortened lifespan”

   Animalshepatocyte-specifichepatocyte-specific knockoutliver

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

Ghr knockout →

1. High-intensity interval training increases telomere length in mice.

   Animalsshort session (≤10 minute)liver10-minute HIIT regimen 3-days-a-week8 weeksfemales

   Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice · The journals of gerontology. Series A, Biological sciences and medical sciences · 25 Sep 2026

2. High-intensity interval training increases Becn1 in mice.

   Animalsshort session (≤10 minute)10-minute HIIT regimen 3-days-a-week8 weeksfemales

   Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice · The journals of gerontology. Series A, Biological sciences and medical sciences · 25 Sep 2026

3. High-intensity interval training increases Ppargc1a in mice.

   Animalsshort session (≤10 minute)10-minute HIIT regimen 3-days-a-week8 weeksfemales

   Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice · The journals of gerontology. Series A, Biological sciences and medical sciences · 25 Sep 2026

4. High-intensity interval training improves cognitive function in mice.

   Animalsshort session (≤10 minute)10-minute HIIT regimen 3-days-a-week8 weeksfemales

   Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice · The journals of gerontology. Series A, Biological sciences and medical sciences · 25 Sep 2026

High-intensity interval training →

1. ULK1 knockout + ULK2 knockout activates mTORC1 signalling in mice.

   Animalsindependent of AKTskeletal muscle

   Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint

2. ULK1 knockout + ULK2 knockout induces skeletal muscle in mice (10-15% in males, 14-20% in females).

   Animalstibialis anterior and soleus

   Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint

3. ULK1 knockout + ULK2 knockout impairs physical function in mice (20% in males, 24% in females).

   Animalslifelong deficiencyskeletal muscle

   Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint

4. ULK1 knockout + ULK2 knockout impairs autophagy in mice.

   Animalslifelong deficiencyskeletal muscle

   Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint

ULK1 knockout + ULK2 knockout →

1. PLX5622 decreases Ang in mice.

   Animalsbrainmales

   Microglial depletion triggers distinct molecular responses in male and female aged mouse brains · bioRxiv : the preprint server for biology · 8 Sep 2026 · Preprint

2. PLX5622 increases Lzts3 in mice.

   Animalsbrainmales

   Microglial depletion triggers distinct molecular responses in male and female aged mouse brains · bioRxiv : the preprint server for biology · 8 Sep 2026 · Preprint

3. PLX5622 decreases miR-223-3p in mice.

   Animalsbrain

   Microglial depletion triggers distinct molecular responses in male and female aged mouse brains · bioRxiv : the preprint server for biology · 8 Sep 2026 · Preprint

4. PLX5622 decreases miR-146a-5p in mice.

   Animalsbrain

   Microglial depletion triggers distinct molecular responses in male and female aged mouse brains · bioRxiv : the preprint server for biology · 8 Sep 2026 · Preprint

PLX5622 →

1. CHK2 inhibition decreases chronic inflammation in mice.

   Animalstransient CHK2 inhibitiongranulosa celltransientfemales

   Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice · bioRxiv · 1 Oct 2026 · Preprint

2. CHK2 inhibition increases blastocyst formation in mice.

   Animalstransient CHK2 inhibitionovarytransientfemales

   Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice · bioRxiv · 1 Oct 2026 · Preprint

3. CHK2 inhibition increases proportion of mature oocytes in mice.

   Animalstransient CHK2 inhibitionovarytransientfemales

   Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice · bioRxiv · 1 Oct 2026 · Preprint

CHK2 inhibition →

1. 4-methylumbelliferone improves recognition memory in mice.

   Animals

   Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice · Glia · 1 Oct 2026

2. 4-methylumbelliferone decreases chronic inflammation in mice.

   Animalsbrain

   Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice · Glia · 1 Oct 2026

3. 4-methylumbelliferone decreases perineuronal nets in mice.

   Animalsbrain

   Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice · Glia · 1 Oct 2026

4-methylumbelliferone →

1. Nkx2-5δhd overexpression decreases frailty in mice.

   Animalssystemic delivery

   Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint

2. Nkx2-5δhd overexpression improves grip strength in mice.

   Animalssystemic delivery

   Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint

3. Nkx2-5δhd overexpression improves visual and electrophysiological function in mice.

   Animalssubretinal deliveryretina

   Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint

Nkx2-5δhd overexpression →

1. Bapta-am inhibits senescence-associated secretory phenotype (SASP) in mice.

   Animalspulmonary fibrosislung

   Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis · Biochimica et biophysica acta. General subjects · 30 Sep 2026

2. Bapta-am protects against pulmonary fibrosis in mice.

   Animalslung

   Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis · Biochimica et biophysica acta. General subjects · 30 Sep 2026

3. Bapta-am decreases cellular senescence in mouse cells.

   Cellssenescence stimulifibroblast

   Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis · Biochimica et biophysica acta. General subjects · 30 Sep 2026

Bapta-am →

1. Neutrophil membrane-encapsulated pd/hceo2 nanoparticles improve blood-brain barrier in mice.

   Animalsin aged PND modelneutrophil membrane-encapsulatedbrain

   Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 30 Sep 2026

2. Neutrophil membrane-encapsulated pd/hceo2 nanoparticles improve cognitive function in mice.

   Animalsin aged PND modelneutrophil membrane-encapsulatedbrain

   Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 30 Sep 2026

3. Neutrophil membrane-encapsulated pd/hceo2 nanoparticles decrease chronic inflammation in mice.

   Animalsin aged PND modelneutrophil membrane-encapsulatedbrain

   Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 30 Sep 2026

Neutrophil membrane-encapsulated pd/hceo2 nanoparticles →

1. PNPLA7 knockout inhibits glycerophosphocholine in mouse cells.

   Cellsmyoblasts

   Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice · Cell reports · 30 Sep 2026

2. PNPLA7 knockout decreases cardiolipin in mice.

   Animalsglobal deficiencyskeletal muscle

   Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice · Cell reports · 30 Sep 2026

3. PNPLA7 knockout impairs physical function in mice.

   Animalsglobal deficiencyquadriceps

   Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice · Cell reports · 30 Sep 2026

PNPLA7 knockout →

1. Coenzyme Q10 increases Cops3 in mice.

   “Proteomic analysis identified increased COPS3 abundance in MKs from CoQ10-treated 24-month-old mice.”

   Animalsmegakaryocyte12 weeksmales

   Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice · Aging cell · 30 Sep 2026

2. Coenzyme Q10 activates autophagy in mice.

   “Changes in the LC3-II/LC3-I ratio and p62 in bone marrow MKs were consistent with enhanced autophagy.”

   Animalsaged micemegakaryocyte12 weeksmales

   Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice · Aging cell · 30 Sep 2026

3. Coenzyme Q10 improves megakaryocyte in mice.

   “CoQ10 enhanced MK proliferation, maturation, and polyploidization in aged mice.”

   Animalsaged micebone marrow12 weeksmales

   Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice · Aging cell · 30 Sep 2026

Coenzyme Q10 →

1. Prevention of hira sumoylation improves preimplantation development rate in mice.

   Animalsin aged oocytesoocytefemales

   Restoring HIRA chromatin maintenance improves aged mouse oocyte quality · bioRxiv · 29 Sep 2026 · Preprint

2. Prevention of hira sumoylation improves oocyte maturation in mice.

   Animalsin aged oocytesoocytefemales

   Restoring HIRA chromatin maintenance improves aged mouse oocyte quality · bioRxiv · 29 Sep 2026 · Preprint

3. Prevention of hira sumoylation increases H3-3a in mice.

   Animalsin aged oocytesoocytefemales

   Restoring HIRA chromatin maintenance improves aged mouse oocyte quality · bioRxiv · 29 Sep 2026 · Preprint

Prevention of hira sumoylation →

1. Chronic restraint stress inhibits autophagy in mice.

   “Mechanistically, transcriptomic profiling and biochemical validation revealed that chronic stress suppresses autophagic pathways via selective hyperactivation of mTORC1 signaling rather than the AMPK pathway.”

   Animalsvia selective hyperactivation of mTORC1 signaling

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

2. Chronic restraint stress increases amyloid-beta in mice.

   “These network deficits were accompanied by accelerated AD hallmarks, including elevated Aβ deposition, dystrophic neurite aggravation, and reactive gliosis.”

   Animalsin 5xFAD mice

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

3. Chronic restraint stress impairs cognitive function in mice.

   “CRS severely impaired cortical slow-wave oscillations and induced aberrant prefrontal single-neuron hyperactivity, exacerbating cognitive decline.”

   Animalsin 5xFAD mice

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

Chronic restraint stress →

1. Aging-resistant ionogel dressing increases collagen in mice.

   Animalsskin

   A magnesium-phenolic hydrogel accelerates wound healing in aged mice · ACS applied materials & interfaces · 28 Sep 2026

2. Aging-resistant ionogel dressing improves wound closure in mice.

   Animalsskin

   A magnesium-phenolic hydrogel accelerates wound healing in aged mice · ACS applied materials & interfaces · 28 Sep 2026

3. Aging-resistant ionogel dressing inhibits apoptosis in mice.

   Animalssenescent microenvironmentskin

   A magnesium-phenolic hydrogel accelerates wound healing in aged mice · ACS applied materials & interfaces · 28 Sep 2026

Aging-resistant ionogel dressing →

1. Tfam knockdown impairs heterosubtypic recall immunity in mice.

   Animalsfollowing influenza infection

   TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint

2. Tfam knockdown increases viral pneumonia in mice.

   Animalsinfluenza infectionlung

   TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint

3. Tfam knockdown induces mitochondrial dysfunction in mice.

   AnimalsCD8+ T cell-specific haploinsufficiencyCD8-positive, alpha-beta T cell

   TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint

Tfam knockdown →

1. Intermittent fasting decreases Sdhaf4 in mice.

   “Mechanistically, ADF downregulates the mitochondrial chaperone SDHAF4, thereby suspending complex II assembly and promoting eNOS-derived nitric oxide (NO) production.”

   Animalsalternate-day fastinghepatocyte

   Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

2. Intermittent fasting increases Nos3 in mice.

   “ADF enhanced hepatocyte eNOS expression, and hepatocyte-specific eNOS knockout abolished the protective metabolic and anti-fibrotic effects of ADF.”

   Animalsalternate-day fastinghepatocyte

   Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

3. Intermittent fasting protects against liver fibrosis in mice.

   “We further establish that the anti-fibrotic benefits of alternate-day fasting (ADF) critically depend on this intercellular pathway.”

   Animalsalternate-day fastingliver

   Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

Intermittent fasting →

1. SEPHIN1 decreases Parkinson's disease in mice.

   Animalsin A53T mice

   Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026

2. SEPHIN1 activates mitophagy in mice.

   Animalsin A53T mice

   Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026

3. SEPHIN1 decreases motor dysfunction in mice.

   Animalsin A53T mice

   Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026

SEPHIN1 →

1. ALDA-1 increases Ppargc1a in mice.

   AnimalsD-galactose-induced aginghippocampus

   Alda-1 Alleviates the Cognitive Deficits in D-galactose-induced Aging Mice by Regulating Oxidative Stress, Neuroinflammation, and Mitochondrial Biogenesis · The journals of gerontology. Series A, Biological sciences and medical sciences · 25 Sep 2026

2. ALDA-1 decreases malondialdehyde in mice.

   AnimalsD-galactose-induced aginghippocampus

   Alda-1 Alleviates the Cognitive Deficits in D-galactose-induced Aging Mice by Regulating Oxidative Stress, Neuroinflammation, and Mitochondrial Biogenesis · The journals of gerontology. Series A, Biological sciences and medical sciences · 25 Sep 2026

3. ALDA-1 improves cognitive function in mice.

   AnimalsD-galactose-induced aging

   Alda-1 Alleviates the Cognitive Deficits in D-galactose-induced Aging Mice by Regulating Oxidative Stress, Neuroinflammation, and Mitochondrial Biogenesis · The journals of gerontology. Series A, Biological sciences and medical sciences · 25 Sep 2026

ALDA-1 →

1. Src inhibitor decreases cognitive deficits in mice.

   Animalsin LPS-challenged mice

   Blocking Src kinase reduces neuroinflammation by activating microglial mitophagy in mice · Biochemical pharmacology · 25 Sep 2026

2. Src inhibitor induces mitophagy in mouse cells.

   Cellsmicroglia

   Blocking Src kinase reduces neuroinflammation by activating microglial mitophagy in mice · Biochemical pharmacology · 25 Sep 2026

3. Src inhibitor decreases neuroinflammation in mice.

   Animalslipopolysaccharide-induced

   Blocking Src kinase reduces neuroinflammation by activating microglial mitophagy in mice · Biochemical pharmacology · 25 Sep 2026

Src inhibitor →

1. Engineered exosome-mimetic lipid nanoparticles decrease chronic inflammation in mice.

   Animalsliver

   Engineered exosome-mimetic nanoparticles improve liver function in aged mice · Biomaterials advances · 24 Sep 2026

2. Engineered exosome-mimetic lipid nanoparticles decrease senescence-associated secretory phenotype in mice.

   Animalsliver

   Engineered exosome-mimetic nanoparticles improve liver function in aged mice · Biomaterials advances · 24 Sep 2026

3. Engineered exosome-mimetic lipid nanoparticles improve liver function in mice.

   Animalsliver

   Engineered exosome-mimetic nanoparticles improve liver function in aged mice · Biomaterials advances · 24 Sep 2026

Engineered exosome-mimetic lipid nanoparticles →

1. High-fat diet increases ubiquitinated mitochondrial proteins in mice.

   Animalscombined with chronic nitric oxide synthase inhibition (L-NAME) in aged micecardiomyocyte

   Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction · American journal of physiology. Heart and circulatory physiology · 19 Sep 2026

2. High-fat diet increases loss of proteostasis in mice.

   Animalscombined with chronic nitric oxide synthase inhibition (L-NAME) in aged micecardiomyocyte

   Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction · American journal of physiology. Heart and circulatory physiology · 19 Sep 2026

3. High-fat diet increases mitochondrial dysfunction in mice.

   Animalscombined with chronic nitric oxide synthase inhibition (L-NAME) in aged miceleft ventricular muscle

   Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction · American journal of physiology. Heart and circulatory physiology · 19 Sep 2026

High-fat diet →

1. Wuzi yanzong pill decreases follicle stimulating hormone in mice.

   AnimalsTripterygium wilfordii polyglycoside-induced DOR model1.82 or 3.64 g/kg28 daysfemalesn = 8

   [Wuzi Yanzong Pill ameliorates diminished ovarian reserve in mice by inhibiting granulosa cell apoptosis via the TGF-β1/PI3K/Akt/mTOR pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

2. Wuzi yanzong pill increases anti-Müllerian hormone in mice.

   AnimalsTripterygium wilfordii polyglycoside-induced DOR model1.82 or 3.64 g/kg28 daysfemalesn = 8

   [Wuzi Yanzong Pill ameliorates diminished ovarian reserve in mice by inhibiting granulosa cell apoptosis via the TGF-β1/PI3K/Akt/mTOR pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

3. Wuzi yanzong pill decreases granulosa cell apoptosis in mice.

   AnimalsTripterygium wilfordii polyglycoside-induced DOR modelovary1.82 or 3.64 g/kg28 daysfemalesn = 8

   [Wuzi Yanzong Pill ameliorates diminished ovarian reserve in mice by inhibiting granulosa cell apoptosis via the TGF-β1/PI3K/Akt/mTOR pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

Wuzi yanzong pill →

1. Prkcq deletion activates autophagy in mice.

   Animalsbleomycin-induced pulmonary fibrosisknockoutlung

   Protein kinase C θ deletion ameliorates bleomycin-induced pulmonary fibrosis via the improvement of SIRT1/AMPK signaling on autophagy and senescence · Iranian journal of basic medical sciences · 1 Jan 2026

2. Prkcq deletion decreases cellular senescence in mice.

   Animalsbleomycin-induced pulmonary fibrosisknockoutlung

   Protein kinase C θ deletion ameliorates bleomycin-induced pulmonary fibrosis via the improvement of SIRT1/AMPK signaling on autophagy and senescence · Iranian journal of basic medical sciences · 1 Jan 2026

3. Prkcq deletion decreases pulmonary fibrosis in mice.

   Animalsbleomycin-inducedknockoutlung

   Protein kinase C θ deletion ameliorates bleomycin-induced pulmonary fibrosis via the improvement of SIRT1/AMPK signaling on autophagy and senescence · Iranian journal of basic medical sciences · 1 Jan 2026

Prkcq deletion →

1. ENPP1 mutation decreases exploration in mice.

   Animalsdependent on STINGH362A point mutation

   Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice · bioRxiv · 2 Oct 2026 · Preprint

2. ENPP1 mutation impairs motor coordination in mice.

   Animalsdependent on STINGH362A point mutation

   Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice · bioRxiv · 2 Oct 2026 · Preprint

ENPP1 mutation →

1. Tet2/3 deletion is associated with genomic instability in mice.

   Animalsfollowing transplantation into recipient miceinvariant natural killer T cell

   TET enzyme deficiency drives the selection of specific aneuploid cells in mice · bioRxiv · 1 Oct 2026 · Preprint

2. Tet2/3 deletion induces lymphoid expansion in mice.

   Animalsinvariant natural killer T cell

   TET enzyme deficiency drives the selection of specific aneuploid cells in mice · bioRxiv · 1 Oct 2026 · Preprint

Tet2/3 deletion →

1. PRODH2 knockdown improves strength in mice.

   Animalsin vivomuscle-specific knockdownskeletal muscle

   Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice · Aging cell · 1 Oct 2026

2. PRODH2 knockdown decreases muscle atrophy in mice.

   Animalsin vivomuscle-specific knockdownskeletal muscle

   Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice · Aging cell · 1 Oct 2026

PRODH2 knockdown →

1. Syringin protects against idiopathic pulmonary fibrosis in mice.

   Animalsbleomycin-induced pulmonary fibrosislung

   Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models · Chinese journal of natural medicines · 1 Oct 2026

2. Syringin decreases cellular senescence in mice.

   Animalsbleomycin-induced pulmonary fibrosislung

   Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models · Chinese journal of natural medicines · 1 Oct 2026

Syringin →

1. Fecal microbiota transplantation activates NLRP3 inflammasome in mice.

   Animalsdonor with ARHLgut microbiota of ARHL patientsspiral ligament

   Gut microbes from hearing loss patients trigger inner ear damage in young mice · Research Square · 30 Sep 2026 · Preprint

2. Fecal microbiota transplantation impairs hearing threshold in mice.

   Animalsdonor with ARHLgut microbiota of ARHL patients

   Gut microbes from hearing loss patients trigger inner ear damage in young mice · Research Square · 30 Sep 2026 · Preprint

Fecal microbiota transplantation →

1. Endothelial mitochondria-targeted chemogenetic hydrogen sulfide decreases age-related pathology in mice.

   Animalsremote-control, endothelial-specific, mitochondria-targeted chemogenetic systemblood vessel

   Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice · bioRxiv · 30 Sep 2026 · Preprint

2. Endothelial mitochondria-targeted chemogenetic hydrogen sulfide decreases cellular senescence in mice.

   Animalsremote-control, endothelial-specific, mitochondria-targeted chemogenetic systemendothelial cell

   Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice · bioRxiv · 30 Sep 2026 · Preprint

Endothelial mitochondria-targeted chemogenetic hydrogen sulfide →

1. Secukinumab protects against temporomandibular joint osteoarthritis in mice.

   Animalsunilateral anterior crossbite modelanti-IL-17A monoclonal antibody

   Interleukin-17A drives joint chondrocyte senescence through mitochondrial dysfunction in mice · Oral diseases · 30 Sep 2026

2. Secukinumab decreases cellular senescence in mice.

   Animalsunilateral anterior crossbite modelanti-IL-17A monoclonal antibodycondylar cartilage

   Interleukin-17A drives joint chondrocyte senescence through mitochondrial dysfunction in mice · Oral diseases · 30 Sep 2026

Secukinumab →

1. INTERLEUKIN-17A increases Opa1 in mouse cells.

   Cellschondrocyte

   Interleukin-17A drives joint chondrocyte senescence through mitochondrial dysfunction in mice · Oral diseases · 30 Sep 2026

2. INTERLEUKIN-17A induces cellular senescence in mouse cells.

   Cellschondrocyte

   Interleukin-17A drives joint chondrocyte senescence through mitochondrial dysfunction in mice · Oral diseases · 30 Sep 2026

INTERLEUKIN-17A →

1. Exercise decreases cellular senescence in mice.

   Animalsdoxorubicin treatmentheart

   Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence · Research Square · 29 Sep 2026 · Preprint

2. Exercise protects against cardiotoxicity in mice.

   Animalsdoxorubicin treatmentheart

   Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence · Research Square · 29 Sep 2026 · Preprint

Exercise →

1. Tnfa increases megakaryocyte in mice.

   Animalscanonical hematopoietic hierarchy

   Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice · bioRxiv · 29 Sep 2026 · Preprint

2. Tnfa increases hematopoietic stem and progenitor cell in mice.

   Animalschronic exposurebone marrow

   Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice · bioRxiv · 29 Sep 2026 · Preprint

Tnfa →

1. CRLS1 restoration decreases mortality in mice.

   Animalsin adult Crls1 knockout mice

   Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor · Nature aging · 29 Sep 2026

2. CRLS1 restoration decreases muscle atrophy in mice.

   Animalsin adult Crls1 knockout miceskeletal muscle

   Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor · Nature aging · 29 Sep 2026

CRLS1 restoration →

1. EN6 improves cognitive function in mice.

   “This microenvironmental stabilization attenuated neuroinflammation, realigned neural networks, and rescued both cognitive and emotional deficits.”

   Animalsafter chronic stress

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

2. EN6 decreases amyloid-beta in mice.

   “Crucially, targeted mTORC1 inhibition with EN6 ameliorated autophagy-related abnormalities and was associated with reduced BACE1 abundance and CTFβ generation, together with a diminished global Aβ burden.”

   AnimalsmTORC1 inhibition

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

EN6 →

1. GFD-CD3 bite decreases age-related pathology in mice.

   “low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”

   Animalsat low doselow-dose

   Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026

2. GFD-CD3 bite decreases cellular senescence in mice.

   “low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”

   Animalsat low doselow-dose

   Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026

GFD-CD3 bite →

1. Alpha-synuclein inhibits autophagy in mouse cells.

   “Mechanistically, α-Syn promoted macrophage foam cell formation by impairing autophagic flux, accompanied by activation of PI3K-mTOR signaling.”

   Cellsmacrophage

   Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026

2. Alpha-synuclein increases atherosclerosis in mice.

   “administration of exogenous α-Syn accelerated atherosclerosis in Apolipoprotein E knockout (Apoe -/- ) mice.”

   Animalsin Apolipoprotein E knockout (Apoe -/- ) miceexogenous

   Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026

Alpha-synuclein →

1. Car-t cell therapy decreases chronic inflammation in mice.

   Animalstargeting of aged inflammatory bone marrow myeloid progenitorsintravenous CAR T cellsbrain

   CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice · bioRxiv · 28 Sep 2026 · Preprint

2. Car-t cell therapy improves cognitive function in mice.

   Animalsin mouse models of aging and Alzheimer's diseaseintrathecal CAR T cells targeting border-associated macrophages

   CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice · bioRxiv · 28 Sep 2026 · Preprint

Car-t cell therapy →

1. Salvianolic acid a protects against atherosclerosis in mice.

   “decreased the size of plaque, and increased the stability of the fibrous cap.”

   Animalsin ApoE -/- mice fed a high-fat diet

   Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

2. Salvianolic acid a decreases cellular senescence in mice.

   “In ApoE -/- mice, SAA reduced the burden of senescent VSMCs, decreased the size of plaque, and increased the stability of the fibrous cap.”

   Animalsin ApoE -/- mice fed a high-fat dietvascular smooth muscle cell

   Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

Salvianolic acid a →

1. Erigeron breviscapus inhibits apoptosis in mice.

   Animalsin SAMP8 mice

   Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice · Biogerontology · 25 Sep 2026

2. Erigeron breviscapus decreases cellular senescence in mice.

   Animalsin SAMP8 miceliver and kidney

   Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice · Biogerontology · 25 Sep 2026

Erigeron breviscapus →

1. Kl knockout decreases Sox2 in mice.

   Animalstongue epithelium

   Reduced SOX2 contributes to taste bud degeneration in accelerated aging mice · Mechanisms of ageing and development · 24 Sep 2026

2. Kl knockout decreases taste bud in mice.

   Animalstongue epithelium

   Reduced SOX2 contributes to taste bud degeneration in accelerated aging mice · Mechanisms of ageing and development · 24 Sep 2026

Kl knockout →

1. Vegfa deletion decreases aqueous humor outflow facility in mice.

   Animalsin CX3CR1+ macrophagesCX3CR1-Cre driven conditional knockoutocular angle

   Macrophage-derived VEGFA helps maintain eye fluid pressure during aging · bioRxiv : the preprint server for biology · 11 Sep 2026 · Preprint

2. Vegfa deletion increases intraocular pressure in mice.

   Animalsin CX3CR1+ macrophagesCX3CR1-Cre driven conditional knockoutocular angle

   Macrophage-derived VEGFA helps maintain eye fluid pressure during aging · bioRxiv : the preprint server for biology · 11 Sep 2026 · Preprint

Vegfa deletion →

1. Tamoxifen has no effect on ovarian aging trajectories in mice.

   Animalslong-termovary12 monthsfemales

   Tamoxifen causes temporary ovarian disruption without altering long-term mouse aging trajectories · bioRxiv : the preprint server for biology · 8 Sep 2026 · Preprint

2. Tamoxifen impairs estrous cyclicity in mice.

   Animalsshortly after administrationovaryfemales

   Tamoxifen causes temporary ovarian disruption without altering long-term mouse aging trajectories · bioRxiv : the preprint server for biology · 8 Sep 2026 · Preprint

Tamoxifen →

1. ANTI-MIR-128 aso protects against Duchenne muscular dystrophy in mice.

   Animalsmouse model of Duchenne muscular dystrophyantisense oligonucleotidestriated muscle

   Inhibiting miR-128-3p restores muscle mass and function in aged mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

2. ANTI-MIR-128 aso improves physical function in mice.

   Animalsfollowing myocardial infarctionantisense oligonucleotideheart

   Inhibiting miR-128-3p restores muscle mass and function in aged mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

ANTI-MIR-128 aso →

1. Nerve growth factor improves hair regeneration in mice.

   Animalswithin arrector pili musclesskinmales

   Sympathetic nerve aging in mouse skin is sexually dimorphic and reversible · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

2. Nerve growth factor increases sympathetic reinnervation in mice.

   Animalswithin arrector pili musclesarrector pili musclemales

   Sympathetic nerve aging in mouse skin is sexually dimorphic and reversible · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

Nerve growth factor →

1. PIEZO1 deletion prevents gastrointestinal motility disorder in mice.

   Animalssmooth muscle Piezo1 deletion in aginggut

   Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

2. PIEZO1 deletion improves physical function in mice.

   Animalsinducible smooth muscle cell-specific deletioninducible smooth muscle cell-specificgut

   Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

PIEZO1 deletion →

1. Larix arabinogalactan decreases chronic inflammation in mice.

   AnimalsD-galactose-induced aging-like modelacid-hydrolyzed arabinose-depleted derivative

   Structure-activity comparison of native larch arabinogalactan and its arabinose-depleted derivative in D-galactose-induced aging-like mice · Carbohydrate polymers · 4 Sep 2026

2. Larix arabinogalactan decreases cellular senescence in mice.

   AnimalsD-galactose-induced aging-like modelacid-hydrolyzed arabinose-depleted derivative

   Structure-activity comparison of native larch arabinogalactan and its arabinose-depleted derivative in D-galactose-induced aging-like mice · Carbohydrate polymers · 4 Sep 2026

Larix arabinogalactan →

1. CD47 antibody decreases cardiac dysfunction in mice.

   “and improved doxorubicin-induced cardiac dysfunction.”

   Animalsdoxorubicin-inducedheartmales

   CD47 blockade reduces doxorubicin-induced cardiac aging in male mice · Physiological reports · 1 Sep 2026

2. CD47 antibody decreases cellular senescence in mice.

   “Blocking CD47 with a specific antibody attenuated doxorubicin-induced cardiac aging and cardiomyocyte senescence in vivo and in vitro”

   Animalsdoxorubicin-inducedheartmales

   CD47 blockade reduces doxorubicin-induced cardiac aging in male mice · Physiological reports · 1 Sep 2026

CD47 antibody →

1. SATB1 deletion induces epigenetic alterations in mice.

   Animalsin naive T cellsconditional knockoutnaive CD4+ T cell

   Loss of SATB1 alters 3D genome architecture in aged mouse T cells · Science advances · 2 Oct 2026

SATB1 deletion →

1. DNMT3A knockout is associated with genomic instability in silico.

   In silicoin lymphomas

   TET enzyme deficiency drives the selection of specific aneuploid cells in mice · bioRxiv · 1 Oct 2026 · Preprint

DNMT3A knockout →

1. Pten knockout induces cellular senescence in mice.

   Animalsprostate-specific conditional knockoutprostatemales

   Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling · Neoplasia (New York, N.Y.) · 1 Oct 2026

Pten knockout →

1. Hindlimb suspension activates Mlxipl in silico.

   In silicogastrocnemius muscleten days

   Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR · PloS one · 1 Oct 2026

Hindlimb suspension →

1. LIN28B overexpression improves hematopoietic reconstitution potential in mouse cells.

   Cellsduring ex vivo expansionhematopoietic stem cell

   Fetal gene Lin28b improves ex vivo expansion of aged mouse blood stem cells · Blood · 1 Oct 2026

LIN28B overexpression →

1. LIN28B knockout induces stem cell exhaustion in mouse cells.

   Cellsfollowing ex vivo expansion cultureshematopoietic stem cell

   Fetal gene Lin28b improves ex vivo expansion of aged mouse blood stem cells · Blood · 1 Oct 2026

LIN28B knockout →

1. NKX2-5 overexpression decreases transcriptomic age in mouse cells.

   Cells

   Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint

NKX2-5 overexpression →

1. Camp knockout increases callus bone in mice.

   Animalsin aged mice

   Cathelicidin peptide aids fracture healing in young mice but impairs it in aged mice · bioRxiv · 30 Sep 2026 · Preprint

Camp knockout →

1. EDA2R knockdown decreases muscle wasting in mice.

   Animalsin SBMA miceskeletal muscle

   Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways · bioRxiv · 30 Sep 2026 · Preprint

EDA2R knockdown →

1. Sleep deprivation induces transcriptomic dynamics in mice.

   Animalstransient stress perturbation and recoverytransient

   Stress and recovery dynamics reveal transcriptomic stability limits across aging mouse organs · bioRxiv · 30 Sep 2026 · Preprint

Sleep deprivation →

1. PD3SN topological quantum biomaterials decrease colorectal cancer in mice (83.4% tumor volume inhibition rate).

   Animalscombined with piperlongumine and ultrasound in subcutaneous and liver metastasis models

   Ultrasound-activated quantum biomaterial pairs with senolytic to suppress colorectal cancer · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 30 Sep 2026

PD3SN topological quantum biomaterials →

1. Fenofibrate decreases monocyte in mice.

   Animalsin chronic traumatic brain injurybrain parenchyma

   Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate · Science translational medicine · 30 Sep 2026

Fenofibrate →

1. Parthenolide protects against localized scleroderma in mice.

   AnimalsF127@PLGA@PTL hydrogel

   Parthenolide reduces senescence and skin fibrosis in scleroderma models · Aging cell · 30 Sep 2026

Parthenolide →

1. Insulin-like growth factor 1 improves physical function in mice.

   “Conversely, exogenous IGF-1 or SLC25A33 overexpression attenuated these effects and partially restored auditory function.”

   Animalscochlea

   IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026

Insulin-like growth factor 1 →

1. SLC25A33 overexpression improves physical function in mice.

   “Conversely, exogenous IGF-1 or SLC25A33 overexpression attenuated these effects and partially restored auditory function.”

   AnimalsAAV-mediatedcochlea

   IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026

SLC25A33 overexpression →

1. Compound 991 induces pro-longevity proteomic profile in mice.

   Animals

   Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026

Compound 991 →

1. Exercise-primed extracellular vesicles improve cartilage in mice.

   Animalscartilage

   Exercise-induced extracellular vesicles enhance aged cartilage health via microRNA-29 · Nature aging · 29 Sep 2026

Exercise-primed extracellular vesicles →

1. CRLS1 deletion induces mitochondrial dysfunction in mice.

   Animalsinducible tissue-specific deletion in young miceinducible tissue-specific deletionskeletal muscle

   Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor · Nature aging · 29 Sep 2026

CRLS1 deletion →

1. Zymosan increases Terf1 in mice.

   Animalswithin 24 h post-injectionjoint24 h

   Low-power infrared laser on telomere maintenance in an experimental model of arthritis · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 29 Sep 2026

Zymosan →

1. MHY1485 increases amyloid-beta 42 in mice.

   “pharmacological mTOR activation with MHY1485 further aggravated autophagic impairment and increased Aβ42 levels.”

   Animalspharmacological mTOR activation

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

MHY1485 →

1. FLOT1 knockdown decreases disabled macroautophagy in mouse cells.

   “Flot1 knockdown reduced α-Syn internalization, PI3K phosphorylation, autophagy impairment, and lipid accumulation”

   Cellsmacrophage

   Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026

FLOT1 knockdown →

1. Snca knockout decreases atherosclerosis in mice.

   “Genetic deletion of α-Syn reduced atherosclerotic lesion size and macrophage lipid accumulation in a mouse model of atherosclerosis induced by overexpression of proprotein convertase subtilisin/kexin type 9 (PCSK9).”

   Animalsinduced by overexpression of PCSK9

   Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026

Snca knockout →

1. Senolytics decrease cellular senescence in mice.

   AnimalsCyclin D2-p21 double-positive senescent macrophagesliver

   A distinct p21-driven macrophage senotype accumulates during aging and liver disease · bioRxiv · 28 Sep 2026 · Preprint

Senolytics →

1. LGALS3 knockout protects against retinal degeneration in mice.

   Animalslater-stage degeneration under prolonged lipid burdenretina

   Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice · bioRxiv · 28 Sep 2026 · Preprint

LGALS3 knockout →

1. Docosahexaenoic acid decreases visual dysfunction in mice.

   Animalsrestoration in DHA-deficient micedietary DHA restorationretina

   Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice · bioRxiv · 28 Sep 2026 · Preprint

Docosahexaenoic acid →

1. Dha deficiency induces oxidative stress and ROS signalling in mice.

   Animalschronicneural retina

   Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice · bioRxiv · 28 Sep 2026 · Preprint

Dha deficiency →

1. Trimethylamine n-oxide increases cellular senescence in mouse cells.

   Cellswith D-galactoseHT22

   Dual cognitive and motor training improves cognitive function in aging rats · Molecular neurobiology · 28 Sep 2026

Trimethylamine n-oxide →

1. Dioscin decreases cellular senescence in mice.

   “In D-galactose-induced senescence models, Dioscin significantly alleviated RPE senescence and EMT.”

   Animalsin D-galactose-induced senescence modelretinal pigment epithelium

   Dioscin attenuates D‑galactose‑induced retinal pigment epithelium senescence and epithelial-mesenchymal transition via the TGF‑β2/PI3K/Akt/β‑catenin pathway · PloS one · 28 Sep 2026

Dioscin →

1. DEPP1 overexpression induces muscle atrophy in mice.

   Animalsskeletal muscle overexpressionskeletal muscle

   Depp1 drives muscle loss under fasting and low oxygen in mice · bioRxiv · 27 Sep 2026 · Preprint

DEPP1 overexpression →

1. DEPP1 knockout decreases muscle atrophy in mice.

   Animalsunder fasting and hypoxiawhole-body knockoutskeletal muscle

   Depp1 drives muscle loss under fasting and low oxygen in mice · bioRxiv · 27 Sep 2026 · Preprint

DEPP1 knockout →

1. Mitochondrial mutagenesis induction induces age-related pathology in mice.

   Animalsconfined to the first two months of lifetwo months

   Early-life mitochondrial DNA mutations drive age-related pathology in mice · bioRxiv · 27 Sep 2026 · Preprint

Mitochondrial mutagenesis induction →

1. PLXDC2 knockdown decreases chronic inflammation in mice.

   “and its silencing attenuates neuroinflammation and oxidative stress.”

   AnimalssiRNA

   Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

PLXDC2 knockdown →

1. Hfn-gm@diplxdc2/dfo/ceo2-np improves motor performance in mice.

   “Crucially, the treatment significantly alleviated dopaminergic neurodegeneration and improved motor performance-including coordination, balance, and endurance in PD mice.”

   Animalsin PD mice

   Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

Hfn-gm@diplxdc2/dfo/ceo2-np →

1. GSK2656157 decreases cellular senescence in mice.

   Animalsin HDM-induced asthma modelairway epithelial cell

   Loss of PP4 drives airway senescence through endoplasmic reticulum stress · Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 27 Sep 2026

GSK2656157 →

1. NOS3 knockout increases liver fibrosis in mice.

   “In human fibrotic liver samples and mouse models, eNOS expression is markedly suppressed, and its hepatocyte-specific deletion aggravates injury and fibrosis.”

   Animalshepatocyte-specifichepatocyte-specific knockoutliver

   Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

NOS3 knockout →

1. HSP90AA1 knockdown protects against atherosclerosis in mice.

   “VSMC-specific HSP90α knockdown mimicked the protective effects of SAA, whereas HSP90α overexpression reversed SAA-mediated effects on disease.”

   AnimalsVSMC-specific knockdown in ApoE -/- miceadeno-associated virus-mediatedvascular smooth muscle cell

   Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

HSP90AA1 knockdown →

1. GRTP1 knockout induces mitochondrial dysfunction in mice.

   “Grtp1 ablation recapitulates aging phenotypes, including oxidative stress, mitochondrial dysfunction, impaired spermatogenesis, and offspring anxiety and social deficits.”

   Animalsgermlinemales

   Protein Grtp1 protects male germlines from aging and prevents offspring behavioral deficits · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

GRTP1 knockout →

1. Sodium arsenite increases left ventricular systolic and diastolic dysfunction in mice.

   Animalsmyocardium10 or 20 mg/L6 weeksmales

   Arsenic triggers heart senescence in mice while quercetin counteracts the damage · Toxicology and applied pharmacology · 26 Sep 2026

Sodium arsenite →

1. PDK4 inhibitor decreases age-related pathology in mice.

   “Pharmacological inhibition of PDK4 in vivo effectively ameliorates the age-related pathologies induced by hepatocyte-specific GHR ablation.”

   Animalsin hepatocyte-specific GHR ablation mice

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

PDK4 inhibitor →

1. Chba decreases cellular senescence in mice.

   Animalsin lamin A knock-in (LAKI) progeroid miceartery

   Lactate receptor activation reduces cellular senescence and protects vascular health in mice · bioRxiv · 25 Sep 2026 · Preprint

Chba →

1. HCAR1 knockout induces cellular senescence in mice.

   Animalsendothelial-specific deletion in young miceendothelial-specific deletionendothelial cell

   Lactate receptor activation reduces cellular senescence and protects vascular health in mice · bioRxiv · 25 Sep 2026 · Preprint

HCAR1 knockout →

1. Unilateral immobilization induces muscle atrophy in mice.

   Animalsdisuseskeletal muscle

   Loss of myofibril number drives muscle fibre atrophy during aging and disuse · The Journal of physiology · 25 Sep 2026

Unilateral immobilization →

1. SRT2104 protects against calcific aortic valve disease in mice.

   AnimalsWestern diet-fed Apoe-/-aortic valve

   Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026

SRT2104 →

1. N-methyl-n-nitrosourea induces apoptosis in mouse cells.

   Cellsmesenchymal stem cell

   Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026

N-methyl-n-nitrosourea →

1. SOX2 knockdown decreases Ntf3 in mouse cells.

   CellssiRNA

   Reduced SOX2 contributes to taste bud degeneration in accelerated aging mice · Mechanisms of ageing and development · 24 Sep 2026

SOX2 knockdown →

1. SOX2 overexpression increases Plcb2 in mouse cells.

   Cells

   Reduced SOX2 contributes to taste bud degeneration in accelerated aging mice · Mechanisms of ageing and development · 24 Sep 2026

SOX2 overexpression →

1. Neisseria flavescens decrease biological age in mice.

   Animalsheat-killed

   Oral bacterium Neisseria flavescens promotes healthspan in worms and rejuvenates aged mice · Nature aging · 24 Sep 2026

Neisseria flavescens →

1. Rapamycin + doxorubicin decreases lung cancer in mice.

   Animalschemoresistant lung cancer modelL1CAM aptamer-modified DPPC nanoliposomeslung

   Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026

Rapamycin + doxorubicin →

1. Ruxolitinib protects against autoimmune demyelination in mice.

   Animals

   Senescent CD4 T cells drive age-associated autoimmunity in mice and humans · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint

Ruxolitinib →

1. Fisetin decreases pathogenic capacity of CD4+ T cells in mice.

   AnimalsCD4-positive alpha-beta T cell

   Senescent CD4 T cells drive age-associated autoimmunity in mice and humans · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint

Fisetin →

1. Caloric restriction increases lipids with higher degrees of unsaturation in mice.

   Animalscortex

   Caloric restriction dynamically alters RNA splicing and lipid composition in mouse brains · bioRxiv · 22 Sep 2026 · Preprint

Caloric restriction →

1. Hesperetin improves hanging test performance in mice.

   “In D-gal-treated mice, hesperetin improved hanging test performance and increased SDH-positive area, particularly during the active phase.”

   Animalsin D-gal-treated miceskeletal muscle100 mg/kg b.w.

   Hesperetin Attenuates Experimentally Induced Skeletal Muscle Dysfunction by Modulating Time-of-Day-Dependent Gene Expression and Mitochondrial Redox-Related Markers · Antioxidants (Basel, Switzerland) · 17 Sep 2026

Hesperetin →

1. Vitamin d decreases thymic involution in mice.

   Reviewthymus

   Vitamin D signaling in thymic development and longevity · Frontiers in nutrition · 15 Sep 2026

Vitamin d →

1. Tek activation protects against age-related changes in mice.

   Animalswild-type miceSchlemm's canal

   Macrophage-derived VEGFA helps maintain eye fluid pressure during aging · bioRxiv : the preprint server for biology · 11 Sep 2026 · Preprint

Tek activation →

1. Apolipoprotein d induces age-related pathology in mice.

   Animalsskeletal muscle

   ApoD drives cellular aging phenotypes through a nuclear mechanotransduction feedback loop · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint

Apolipoprotein d →

1. ULK1 knockdown + ULK2 knockdown induces skeletal muscle in mice (13%).

   Animalsplasmid-encoded microRNA electroporationskeletal muscleup to 4 weeks

   Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint

ULK1 knockdown + ULK2 knockdown →

1. Methionine restriction has no effect on pro-metabolic effects in mice.

   Animalswith normal cysteine in Cth-deficient mice

   Cysteine restriction extends lifespan and boosts metabolic fitness in animals · bioRxiv : the preprint server for biology · 9 Sep 2026 · Preprint

Methionine restriction →

1. Cysteine restriction improves healthspan in mice.

   Animalsin aged Cth -/- mice70% reduction70% cysteine reduction

   Cysteine restriction extends lifespan and boosts metabolic fitness in animals · bioRxiv : the preprint server for biology · 9 Sep 2026 · Preprint

Cysteine restriction →

1. Gonadectomy decreases divergent aging trajectories in mice.

   Animalsearly gonadectomy

   Sympathetic nerve aging in mouse skin is sexually dimorphic and reversible · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

Gonadectomy →

1. Staphylococcus aureus infection decreases T cell in mice.

   Animalsin older miceepicutaneous infectionskin

   Aging remodels skin immune responses to infection and sensitization in mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

Staphylococcus aureus infection →

1. PIEZO1 activation impairs physical function in mice.

   Animalsin young micegut

   Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint

PIEZO1 activation →

1. MIR-193B-3P improves histological recovery in mice.

   Animalsvolumetric muscle loss modelskeletal muscle

   Extracellular vesicle microRNA promotes muscle regeneration by suppressing AP2M1 · Molecular therapy. Nucleic acids · 3 Sep 2026

MIR-193B-3P →

1. Doxorubicin increases Cd47 in mice.

   “Doxorubicin increased p53, p16, and p21 expression in mouse hearts, accompanied by marked CD47 upregulation.”

   Animalsheartmales

   CD47 blockade reduces doxorubicin-induced cardiac aging in male mice · Physiological reports · 1 Sep 2026

Doxorubicin →

1. MDIVI-1 decreases muscle atrophy in mice.

   “Mdivi-1 treatment produced similar protective effects, including attenuation of skeletal muscle atrophy, oxidative stress, and inflammatory responses.”

   AnimalsHFD-fed miceskeletal muscle

   Aerobic Exercise Attenuates High-Fat Diet-Induced Skeletal Muscle Atrophy by Suppressing Oxidative Stress, Inflammation, and Drp1-Associated Mitochondrial Fission · Antioxidants (Basel, Switzerland) · 31 Aug 2026

MDIVI-1 →

1. Aerobic exercise decreases muscle atrophy in mice.

   “Aerobic exercise reduced Drp1 phosphorylation, oxidative stress, and inflammatory responses in the skeletal muscle of HFD-fed mice and attenuated skeletal muscle atrophy.”

   AnimalsHFD-fed miceskeletal muscle8-week

   Aerobic Exercise Attenuates High-Fat Diet-Induced Skeletal Muscle Atrophy by Suppressing Oxidative Stress, Inflammation, and Drp1-Associated Mitochondrial Fission · Antioxidants (Basel, Switzerland) · 31 Aug 2026

Aerobic exercise →

1. FUNDC1 overexpression protects against skin photoaging in mice.

   “FUNDC1 overexpression attenuated these changes in vitro and in vivo.”

   Animalsunder UVA exposureskin

   FUNDC1 protects skin against UVA damage through mitophagy and P53 stability · Antioxidants (Basel, Switzerland) · 25 Aug 2026

FUNDC1 overexpression →