Epigenetic alterations
Hallmark of aging62 papers9 findings
A human study links epigenetic alterations in blood to frailty, while mouse and cell experiments reveal specific genetic regulators. Reviews describe these alterations as contributing to cancer, neuroinflammation and mitochondrial dysfunction, but mitigated by exercise.
- Human trial3
- Humans16
- Animals6
- Model organisms6
- Cells7
- In silico2
Interventions
2SATB1 deletion
upin mice1
1 study
SATB1 deletion
upin mice1
SATB1 deletion induces epigenetic alterations in mice.
Animalsin naive T cellsconditional knockoutnaive CD4+ T cell
Loss of SATB1 alters 3D genome architecture in aged mouse T cells · Science advances · 2 Oct 2026
Exercise
downin reviews1
1 study
Exercise
downin reviews1
Exercise decreases epigenetic alterations.
Review
Integrated Multi-Omics Network by Physical Exercise Across Aging: Molecular Adaptation Beyond Single Signaling Pathways · Physiological genomics · 21 Sep 2026
Effects
2Chronic inflammation
upin humans1
1 study
Chronic inflammation
upin humans1
Epigenetic alterations increase chronic inflammation in humans.
Reviewin chronic environmental exposuresbrain
Neuroepigenetics of the Environmental Exposome: Molecular and Clinical Implications in Neurodegeneration · The neurologist · 28 Sep 2026
Mitochondrial dysfunction
upin humans1
1 study
Mitochondrial dysfunction
upin humans1
Epigenetic alterations increase mitochondrial dysfunction in humans.
Reviewin chronic environmental exposuresbrain
Neuroepigenetics of the Environmental Exposome: Molecular and Clinical Implications in Neurodegeneration · The neurologist · 28 Sep 2026
Upstream
2NPM1
is required forin human cells1
1 study
NPM1
is required forin human cells1
NPM1 is required for epigenetic alterations in human cells.
Cellsfor nucleolar buffering and heterochromatin maintenance under Progerin stress
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells · bioRxiv · 1 Oct 2026 · Preprint
UHRF1
downin cells1
1 study
UHRF1
downin cells1
UHRF1 protects against epigenetic alterations in cells.
Cellsat late-replicating, CpG-sparse genomic regions
A UHRF1 feed-forward mechanism sustains DNA methylation at CpG-sparse genomic regions · bioRxiv · 26 Sep 2026 · Preprint
Associations
3Frailty index
mixedin humans1
1 study
Frailty index
mixedin humans1
Frailty index is associated with epigenetic alterations in humans (448 differentially methylated regions and 488 differentially variable regions).
Humansbloodn = 1,445
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity · bioRxiv : the preprint server for biology · 25 Sep 2026 · Preprint
Renal tubular epithelial cell
upin human cells1
1 study
Renal tubular epithelial cell
upin human cells1
Renal tubular epithelial cell is associated with epigenetic alterations in human cells.
Cellsin diseased kidneyskidney
Kidney tubular epithelial cells drive accelerated epigenetic aging in disease · Nature aging · 24 Sep 2026
Cancer
upin humans1
1 study
Cancer
upin humans1
Epigenetic alterations raise the risk of cancer in humans.
“Age-related epigenetic alterations can promote cancer, which exploits plasticity for evolution, immune evasion, metastasis, and resistance.”
Review
The Epigenetic Aging-Cancer Continuum: Biomarkers, Metabolism, and Therapy · Genes · 16 Sep 2026
Latest
62Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
bioRxiv · Yeewa R et al.
Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
bioRxiv · Olova NN et al.
Loss of SATB1 alters 3D genome architecture in aged mouse T cells
Declining levels of the chromatin organizer SATB1 disrupt genomic boundaries and drive inflammatory gene activation in naive CD4+ T cells.
Science advances · Wang B et al.
Multi-omics analysis reveals molecular networks driving muscle decline in aging vervet monkeys
Researchers identified coordinated changes in DNA methylation, miRNAs, and gene expression distinguishing older female monkeys with slower gait from middle-aged counterparts.
bioRxiv · Patel MS et al.
TET enzyme deficiency drives the selection of specific aneuploid cells in mice
Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.
bioRxiv · López-Moyado IF et al.
Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
bioRxiv · Yang L et al.
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.
bioRxiv · Mungo C et al.
Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Genome medicine · Jonkman TH et al.
DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · Simpson DJ et al.
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
bioRxiv · Alsolami S et al.