Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system
AnimalsEuropean journal of translational myology
Topic
Mitochondria
Mitochondrial function, mitophagy and energy decline with age.
YesterdayFri 2 OctFriday 2 October4 papers
AnimalsPreprint
Inhibiting miR-128-3p restores muscle mass and function in aged mice
The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.
bioRxiv : the preprint server for biology · Boldridge MA et al.
AnimalsPeer-reviewed
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · Chen G et al.
Thu 1 Oct9 papers
Model organismsPeer-reviewed
USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms
A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.
Cell reports · Gordillo-García S et al.
Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss
ReviewMolecular neurobiology
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
ReviewFrontiers in molecular neuroscience
AnimalsPeer-reviewed
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
Cell reports · Matsumoto S et al.
Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies
ReviewAgeing research reviews
AnimalsPeer-reviewed
D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway
The rare sugar enhances mitophagy, blocks cGAS-STING signaling, and protects nucleus pulposus cells from senescence and apoptosis.
Experimental & molecular medicine · Zhao Z et al.
AnimalsPeer-reviewed
Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice
The flavonoid engages PINK1 to curb microglial pyroptosis and mitochondrial stress in models of Alzheimer's disease.
Chinese journal of natural medicines · Fan L et al.
Regulation of cellular proteostasis via mitochondrial protein import
ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms
ReviewMini reviews in medicinal chemistry
Wed 30 Sep8 papers
AnimalsPeer-reviewed
Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor
Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.
Nature aging · Finger F et al.
Model organismsPreprint
A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria
Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity declines with age.
bioRxiv · Tsagkari D et al.
AnimalsPeer-reviewed
Parthenolide reduces senescence and skin fibrosis in scleroderma models
The compound targets Ero1L to stabilize contacts between mitochondria and the endoplasmic reticulum, mitigating tissue damage in cells and mice.
Aging cell · Wang F et al.
Increased mtDNA Polymorphism Level and Defective Mitophagy are Associated With Proinflammatory Activation in THP-1-Based Cybrids
CellsFrontiers in bioscience (Elite edition)
AnimalsPeer-reviewed
Mitochondrial antioxidant MitoQ reduces Alzheimer's pathology in symptomatic mice
Oral treatment improved behavioral deficits, suppressed amyloid plaques, lowered neuroinflammation, and restored mitochondrial quality control in mice with established disease.
Aging and disease · Kumar M et al.
Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies
ReviewDiabetes, metabolic syndrome and obesity : targets and therapy
Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels
CellsJournal of Alzheimer's disease : JAD
Tue 29 Sep5 papers
Sarcopenia as a manifestation of systemic energetic failure with ageing
ReviewThe lancet. Healthy longevity
AnimalsPreprint
Depp1 drives muscle loss under fasting and low oxygen in mice
The study reveals that the protein localizes to mitochondria to regulate autophagy and mitochondrial degradation during nutrient and oxygen limitation.
bioRxiv · Qayyum S et al.
AnimalsPreprint
Crebanine protects aged rats from anesthesia-induced cognitive deficits by restoring mitophagy
The compound suppresses mitochondrial DNA leakage and the cGAS-STING inflammatory pathway in microglial cells following sevoflurane exposure.
Research Square · Zheng G et al.
Mon 28 Sep10 papers
AnimalsPreprint
Early-life mitochondrial DNA mutations drive age-related pathology in mice
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.
bioRxiv · Shemtov SJ et al.
Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
ReviewReproductive medicine and biology
AnimalsPeer-reviewed
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · Chen X et al.
Model organismsPeer-reviewed
Lipid metabolism regulators and snoRNPs control mitochondrial surveillance and mitophagy
Supplementing unsaturated fatty acids enhanced mitochondrial stress responses and pathogen defense without altering the unfolded protein response.
GeroScience · Armendariz L et al.
Model organismsPeer-reviewed
Targeted metal modulation preserves retinal structure and vision in zebrafish
Telomir-Zn depleted labile iron, lowered oxidative stress, and improved visual behaviors and epigenetic marks in zebrafish and cultured human retinal cells.
International journal of molecular sciences · Angel I et al.
AnimalsPreprint
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity
Declining TFAM levels impair mitochondrial function in CD8+ T cells, driving tissue damage and weakening long-term immune protection during influenza.
bioRxiv · Navaeiseddighi Z et al.
CellsPeer-reviewed
Zinc influx promotes mitophagy to slow intervertebral disc degeneration
Targeting the zinc transporter ZIP14 and ANXA2 deacetylation restores autophagic flux and limits degenerative spinal disease in experimental models.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Jin Y et al.
Mitochondrial Quality Control Imbalance in the Heterogeneity of Parkinson's Disease: From Selective Vulnerability to Stratified Transformation
ReviewInternational journal of molecular sciences
Mitochondrial Ca²⁺ homeostasis in ovarian function and oocyte competence: from molecular transporters to early embryonic development
ReviewFrontiers in cell and developmental biology