Rapamycin
InterventionmTOR inhibitors4 papers7 findingsPubChem 5284616ChEBI 9168
Rapamycin inhibits cellular senescence in human cells and mice. In mouse models, it protects against pulmonary fibrosis, inhibits tumour mTOR signalling, and activates autophagy, while reviews confirm it inhibits mTOR signalling.
- Animals3
- Cells1
Outcomes
5Cellular senescence
downin human cells1downin mice1
2 studies
Cellular senescence
downin human cells1downin mice1
Rapamycin inhibits cellular senescence in human cells.
Cellsepithelial cell
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint
Rapamycin decreases cellular senescence in mice.
Animalstherapy-induced senescence in chemoresistant lung cancertumor
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026
mTOR signalling
downin mice1downin reviews1
2 studies
mTOR signalling
downin mice1downin reviews1
Rapamycin inhibits mTOR signalling.
Review
Rapamycin across biology and medicine: From molecular mechanisms to clinical and translational frontiers · Biochimica et biophysica acta. General subjects · 24 Sep 2026
Rapamycin inhibits mTOR signalling in mice.
Animalsin chemoresistant lung cancertumor
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026
Pulmonary fibrosis
downin mice1
1 study
Pulmonary fibrosis
downin mice1
Rapamycin protects against pulmonary fibrosis in mice.
Animalsbleomycin-induced pulmonary fibrosislung
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint
SFN
downin human cells1
1 study
SFN
downin human cells1
Rapamycin decreases SFN in human cells.
CellsA549
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint
Autophagy
upin mice1
1 study
Autophagy
upin mice1
Rapamycin activates autophagy in mice.
Animalstumor
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026
Latest
6Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer
The formulation co-delivers rapamycin and doxorubicin across the mucus barrier to inhibit mTOR and suppress tumor growth without evident systemic toxicity.
Biomaterials · Man Y et al.
Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice
The supplement boosted autophagy via COPS3, enhancing megakaryocyte maturation and polyploidization without altering baseline platelet counts.
Aging cell · Xu Y et al.
Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.
Research Square · Liu M et al.
FUNDC1 protects skin against UVA damage through mitophagy and P53 stability
Researchers identified a molecular pathway where FUNDC1 preserves mitochondrial quality and works with BAZ1B to regulate P53 during skin photoaging.
Antioxidants (Basel, Switzerland) · Zhang C et al.