GFD-CD3 bite
Intervention1 paper5 findings
- Animals1
Outcomes
3Age-related pathology
downin mice1downin non-human primates1
1 study
Age-related pathology
downin mice1downin non-human primates1
GFD-CD3 bite decreases age-related pathology in non-human primates.
“low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”
Animalsat low doselow-dose
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
GFD-CD3 bite decreases age-related pathology in mice.
“low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”
Animalsat low doselow-dose
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
Cellular senescence
downin mice1downin non-human primates1
1 study
Cellular senescence
downin mice1downin non-human primates1
GFD-CD3 bite decreases cellular senescence in non-human primates.
“low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”
Animalsat low doselow-dose
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
GFD-CD3 bite decreases cellular senescence in mice.
“low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”
Animalsat low doselow-dose
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
Hepatotoxicity
upin animals1
1 study
Hepatotoxicity
upin animals1
GFD-CD3 bite induces hepatotoxicity.
“high-dose GFD-CD3 predominantly induced hepatotoxicity through T cell-mediated attack on hepatic endothelial cells.”
Animalshigh-dosehepatic endothelial cellshigh-dose
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
Latest
1Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates
Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.
Aging cell · Deng J et al.