Snca knockout
Intervention1 paper1 finding
- Animals1
Outcomes
1Atherosclerosis
downin mice1
1 study
Atherosclerosis
downin mice1
Snca knockout decreases atherosclerosis in mice.
“Genetic deletion of α-Syn reduced atherosclerotic lesion size and macrophage lipid accumulation in a mouse model of atherosclerosis induced by overexpression of proprotein convertase subtilisin/kexin type 9 (PCSK9).”
Animalsinduced by overexpression of PCSK9
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026
Latest
1AnimalsmTOR & rapamycin
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.