Loss of proteostasis

1. Otulin knockdown increases loss of proteostasis in cells.

   Cells

   Excess linear ubiquitination disrupts aggregate clearance and impairs proteostasis in cells · The EMBO journal · 28 Sep 2026

Otulin knockdown →

1. Turnera diffusa polysaccharides protect against loss of proteostasis.

   Model organisms

   Turnera diffusa polysaccharides promote healthy aging through conserved stress response regulation and metabolic remodeling across multiple aging models · Biogerontology · 25 Sep 2026

Turnera diffusa polysaccharides →

1. Exercise decreases loss of proteostasis.

   Review

   Integrated Multi-Omics Network by Physical Exercise Across Aging: Molecular Adaptation Beyond Single Signaling Pathways · Physiological genomics · 21 Sep 2026

Exercise →

1. High-fat diet increases loss of proteostasis in mice.

   Animalscombined with chronic nitric oxide synthase inhibition (L-NAME) in aged micecardiomyocyte

   Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction · American journal of physiology. Heart and circulatory physiology · 19 Sep 2026

High-fat diet →

1. Epoxomicin increases loss of proteostasis in human cells.

   “Physiological restoration of proteasome-inhibited RBCs caused accelerated ATP depletion, massive protein aggregation, reduced deformability, hemolysis, and phosphatidylserine exposure”

   Cellsduring physiological restorationerythrocyte

   Proteasome activity maintains red blood cell integrity during storage and restoration · Antioxidants (Basel, Switzerland) · 9 Sep 2026

Epoxomicin →

1. Curcumin decreases loss of proteostasis in D. discoideum.

   “Thioflavin T (ThT) and Congo Red assays demonstrated a marked reduction in amyloid-like polyQ aggregates following treatment.”

   Model organismsin 80Q-expressing cells

   Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease · Biomedicines · 28 Aug 2026

Curcumin →

1. Resveratrol decreases loss of proteostasis in D. discoideum.

   “Thioflavin T (ThT) and Congo Red assays demonstrated a marked reduction in amyloid-like polyQ aggregates following treatment.”

   Model organismsin 80Q-expressing cells

   Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease · Biomedicines · 28 Aug 2026

Resveratrol →

1. Metformin decreases loss of proteostasis in D. discoideum.

   “Thioflavin T (ThT) and Congo Red assays demonstrated a marked reduction in amyloid-like polyQ aggregates following treatment.”

   Model organismsin 80Q-expressing cells

   Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease · Biomedicines · 28 Aug 2026

Metformin →

1. Loss of proteostasis mediates synucleinopathies in humans.

   Reviewdepending on clearance capacity of diverse aggregates

   Differential proteostasis imbalance and the molecular basis of distinct synucleinopathies and tauopathies · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

Synucleinopathies →

1. defects in mitochondrial protein import induces loss of proteostasis.

   Reviewmislocalization of precursor proteins to the cytosol

   Regulation of cellular proteostasis via mitochondrial protein import · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

1. mitochondrial protein import mediates loss of proteostasis.

   Review

   Regulation of cellular proteostasis via mitochondrial protein import · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

1. Heat shock response and chaperones decrease loss of proteostasis.

   Reviewcytosol/nucleus

   More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

Heat shock response and chaperones →

1. Dysbiosis is associated with loss of proteostasis.

   Review

   The microbiota-proteostasis axis: implications in neurodegenerative diseases · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026

Dysbiosis →

1. Ubiquitin–proteasome system is associated with loss of proteostasis in silico.

   In silicoin AD brain transcriptomicsbrain

   A multi-region transcriptomic framework reveals global and region-specific ubiquitin-proteasome system biomarkers in Alzheimer's disease · Functional & integrative genomics · 29 Sep 2026

Ubiquitin–proteasome system →

1. Homo sapiens are associated with loss of proteostasis in human cells.

   Cellsduring agingneuron

   Human neurons accumulate far more mutations over lifespan than shorter-lived mammals · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint

Homo sapiens →