PLXDC2 knockdown
Intervention1 paper1 finding
- Animals1
Outcomes
1Chronic inflammation
downin mice1
1 study
Chronic inflammation
downin mice1
PLXDC2 knockdown decreases chronic inflammation in mice.
“and its silencing attenuates neuroinflammation and oxidative stress.”
AnimalssiRNA
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Latest
1AnimalsCellular senescence
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice
Silencing the upregulated gene PLXDC2 via brain-penetrating nanoparticles suppressed cGAS-STING signaling, reduced iron accumulation, and protected dopaminergic neurons.