CRLS1 restoration

Intervention1 paper2 findings

Outcomes

Mortality

downin mice1

1 study

CRLS1 restoration decreases mortality in mice.
Animalsin adult Crls1 knockout mice
Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor · Nature aging · 29 Sep 2026

Muscle atrophy

downin mice1

1 study

CRLS1 restoration decreases muscle atrophy in mice.
Animalsin adult Crls1 knockout miceskeletal muscle
Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor · Nature aging · 29 Sep 2026

AnimalsPeer-reviewedMitochondria30 Sep

Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.

Nature aging · Finger F et al.