SRT2104
Intervention1 paper1 findingPubChem 25108829
- Animals1
Outcomes
1Calcific aortic valve disease
downin mice1
1 study
Calcific aortic valve disease
downin mice1
SRT2104 protects against calcific aortic valve disease in mice.
AnimalsWestern diet-fed Apoe-/-aortic valve
Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026
Latest
1AnimalsNAD+ & sirtuins
Activating Sirt1 reduces aortic valve calcification in mice and human cells
The sirtuin protects valves by activating the Nrf2 pathway, preserving mitochondrial function, and preventing iron-driven ferroptosis.