EN6
Intervention1 paper2 findingsPubChem 99640033
- Animals1
Outcomes
2Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
EN6 improves cognitive function in mice.
“This microenvironmental stabilization attenuated neuroinflammation, realigned neural networks, and rescued both cognitive and emotional deficits.”
Animalsafter chronic stress
Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026
Amyloid-beta
downin mice1
1 study
Amyloid-beta
downin mice1
EN6 decreases amyloid-beta in mice.
“Crucially, targeted mTORC1 inhibition with EN6 ameliorated autophagy-related abnormalities and was associated with reduced BACE1 abundance and CTFβ generation, together with a diminished global Aβ burden.”
AnimalsmTORC1 inhibition
Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026
Latest
1Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1
Inhibiting mTORC1 restored autophagy, reduced amyloid accumulation, and corrected circuit desynchronization and behavioral deficits in stressed Alzheimer model mice.
CNS neuroscience & therapeutics · Zou Y et al.