p53–p21 pathway
Pathway31 papers3 findings
- Humans1
- Animals17
- Model organisms1
- Cells8
Interventions
3Shikonin
downin rats1
1 study
Shikonin
downin rats1
Shikonin inhibits p53–p21 pathway in rats.
Animalsdoxorubicin-treated
Shikonin attenuates doxorubicin-induced myocardial senescence and fibrosis in association with improved redox and mitochondrial homeostasis · Molecular biology reports · 28 Sep 2026
Mitomycin c
upin human cells1
1 study
Mitomycin c
upin human cells1
Mitomycin c activates p53–p21 pathway in human cells.
Cellsumbilical cord mesenchymal stem cell1.5 μg/mL7 days
Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C · Bulletin of experimental biology and medicine · 28 Sep 2026
Sodium arsenite
upin rat cells1
1 study
Sodium arsenite
upin rat cells1
Sodium arsenite activates p53–p21 pathway in rat cells.
Cells
Arsenic triggers heart senescence in mice while quercetin counteracts the damage · Toxicology and applied pharmacology · 26 Sep 2026
Latest
31Senescent CD4 T cells drive age-associated autoimmunity in mice and humans
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
bioRxiv : the preprint server for biology · McCarthy EC et al.
Pathogenic modulators of cellular senescence
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · Chen G et al.
DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · Simpson DJ et al.
Ormeloxifene, a non-steroidal selective estrogen receptor modulator induces senescence in breast cancer cells
Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chinese journal of natural medicines · Wang Y et al.