HSP90AA1 knockdown
Intervention1 paper1 finding
- Animals1
Outcomes
1Atherosclerosis
downin mice1
1 study
Atherosclerosis
downin mice1
HSP90AA1 knockdown protects against atherosclerosis in mice.
“VSMC-specific HSP90α knockdown mimicked the protective effects of SAA, whereas HSP90α overexpression reversed SAA-mediated effects on disease.”
AnimalsVSMC-specific knockdown in ApoE -/- miceadeno-associated virus-mediatedvascular smooth muscle cell
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Latest
1AnimalsCellular senescence
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.