Disabled macroautophagy
Hallmark of aging75 papers1 finding
- Humans3
- Animals22
- Model organisms5
- Cells12
- In silico1
Interventions
1FLOT1 knockdown
downin mouse cells1
1 study
FLOT1 knockdown
downin mouse cells1
FLOT1 knockdown decreases disabled macroautophagy in mouse cells.
“Flot1 knockdown reduced α-Syn internalization, PI3K phosphorylation, autophagy impairment, and lipid accumulation”
Cellsmacrophage
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026
Latest
75Rank normalization resolves distinct proteome degradation pathways in cultured cells
A percentile-based normalization method reveals substrate preferences between proteasomal and lysosomal clearance systems in cultured cells.
bioRxiv · Gao Z et al.
Aging mouse brains accumulate myelin lipids that drive lysosomal dysfunction
Lysosomal multi-omics shows altered sphingolipid breakdown leads to glycosphingolipid buildup and lysosome enlargement, especially in aging microglia.
Cell reports · Sarkar C et al.
The therapeutic potential of melatonin: Focus on the SIRT1 signaling pathway
Traditional Chinese medicine-derived natural products and formulations as pharmacological modulators of ageing-related pathways: mechanisms and therapeutic potential
Crosstalk between exosomes and cellular senescence: A core vicious loop promoting α-synuclein pathology in Parkinson's disease
Proteostasis and ageing dissidence
Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease
Neuroinflammation and Autophagy in Neurodegeneration: Cellular Mechanisms and Therapeutic Strategies
D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway
The rare sugar enhances mitophagy, blocks cGAS-STING signaling, and protects nucleus pulposus cells from senescence and apoptosis.
Experimental & molecular medicine · Zhao Z et al.