Doxorubicin
Intervention7 papers2 findingsPubChem 31703ChEBI 28748MeSH D004317
- Animals4
- Cells3
Outcomes
2Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
Doxorubicin induces cellular senescence in human cells.
“Here we show that doxorubicin-induced senescence disrupts mitochondrial function in primary human astrocytes and compromises their capacity to sustain neuronal bioenergetics.”
Cellsastrocyte
Senescent human astrocytes impair neuronal mitochondrial function through released factors · Antioxidants (Basel, Switzerland) · 6 Sep 2026
Cd47
upin mice1
1 study
Cd47
upin mice1
Doxorubicin increases Cd47 in mice.
“Doxorubicin increased p53, p16, and p21 expression in mouse hearts, accompanied by marked CD47 upregulation.”
Animalsheartmales
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice · Physiological reports · 1 Sep 2026
Latest
7Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Frontiers in pharmacology · Yang K et al.
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Neoplasia (New York, N.Y.) · Lin C et al.
Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence
Physical activity preserved cardiac function and sustained FNDC5 and irisin signaling in mice exposed to doxorubicin.
Research Square · Jeyabal P et al.
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer
The formulation co-delivers rapamycin and doxorubicin across the mucus barrier to inhibit mTOR and suppress tumor growth without evident systemic toxicity.
Biomaterials · Man Y et al.
Senescent human astrocytes impair neuronal mitochondrial function through released factors
Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.
Antioxidants (Basel, Switzerland) · Amorim P et al.
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice
Inhibiting CD47 lessens heart dysfunction and blunts cellular senescence caused by the chemotherapy drug doxorubicin.
Physiological reports · Yan A et al.