Mitochondrial dysfunction

1. Natural products decrease mitochondrial dysfunction.

   Reviewin diabetic kidney diseasekidney

   The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms · Mini reviews in medicinal chemistry · 30 Sep 2026

Natural products →

1. SEX-1 knockdown induces mitochondrial dysfunction in worms.

   Model organismsloss of function

   A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria · bioRxiv · 29 Sep 2026 · Preprint

SEX-1 knockdown →

1. CRLS1 deletion induces mitochondrial dysfunction in mice.

   Animalsinducible tissue-specific deletion in young miceinducible tissue-specific deletionskeletal muscle

   Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor · Nature aging · 29 Sep 2026

CRLS1 deletion →

1. SOD2 proximal apa site mutation increases mitochondrial dysfunction in fission yeast cells.

   Cellsin a mitophagy-deficient (atg43Δ) background

   Alternative polyadenylation regulates mitochondrial sod2 during yeast quiescence transitions · bioRxiv · 28 Sep 2026 · Preprint

SOD2 proximal apa site mutation →

1. Mitomycin c has no effect on mitochondrial dysfunction in human cells.

   Cellsumbilical cord mesenchymal stem cell1.5 μg/mL7 days

   Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C · Bulletin of experimental biology and medicine · 28 Sep 2026

Mitomycin c →

1. Astragaloside iv protects against mitochondrial dysfunction in mouse cells.

   Cellscardiomyocyte

   Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 28 Sep 2026

Astragaloside iv →

1. Tfam knockdown induces mitochondrial dysfunction in mice.

   AnimalsCD8+ T cell-specific haploinsufficiencyCD8-positive, alpha-beta T cell

   TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint

Tfam knockdown →

1. GRTP1 knockout induces mitochondrial dysfunction in mice.

   “Grtp1 ablation recapitulates aging phenotypes, including oxidative stress, mitochondrial dysfunction, impaired spermatogenesis, and offspring anxiety and social deficits.”

   Animalsgermlinemales

   Protein Grtp1 protects male germlines from aging and prevents offspring behavioral deficits · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

GRTP1 knockout →

1. Inotodiol decreases mitochondrial dysfunction in mice.

   Animalsskeletal muscle

   Inotodiol preserves muscle mass and function in aged mice · Signal transduction and targeted therapy · 25 Sep 2026

Inotodiol →

1. High-fat diet increases mitochondrial dysfunction in mice.

   Animalscombined with chronic nitric oxide synthase inhibition (L-NAME) in aged miceleft ventricular muscle

   Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction · American journal of physiology. Heart and circulatory physiology · 19 Sep 2026

High-fat diet →

1. Mitochondrial dysfunction induces chronic inflammation.

   Review

   Mitochondria and associated complexes as therapeutic targets in aging: From biomacromolecular structure-function insights to clinical translation · Mitochondrion · 1 Oct 2026

2. Mitochondrial dysfunction increases chronic inflammation in humans.

   Review

   Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder · Nature reviews. Nephrology · 24 Sep 2026

Chronic inflammation →

1. Mitochondrial dysfunction induces cellular senescence.

   Review

   Mitochondria and associated complexes as therapeutic targets in aging: From biomacromolecular structure-function insights to clinical translation · Mitochondrion · 1 Oct 2026

2. Mitochondrial dysfunction induces cellular senescence in humans.

   “These interconnected processes promote vascular smooth muscle cell (VSMC) phenotypic switching, apoptosis, and senescence”

   Reviewvascular smooth muscle cell

   Mitochondrial dysfunction in aortic aneurysm and dissection: mechanisms and therapeutic implications · Frontiers in pharmacology · 10 Sep 2026

Cellular senescence →

1. Mitochondrial dysfunction activates apoptosis.

   Review

   Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies · Ageing research reviews · 30 Sep 2026

Apoptosis →

1. Mitochondrial dysfunction increases tau protein in human cells.

   Cells

   Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels · Journal of Alzheimer's disease : JAD · 29 Sep 2026

Tau protein →

1. Mitochondrial dysfunction decreases bioenergetic reserve in humans.

   Review

   Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder · Nature reviews. Nephrology · 24 Sep 2026

1. Mitochondrial dysfunction impairs pancreatic beta cell in humans.

   Reviewin T2Dpancreatic beta cell

   Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies · Diabetes, metabolic syndrome and obesity : targets and therapy · 23 Sep 2026

1. Oxidative stress and ROS signalling induces mitochondrial dysfunction.

   Review

   Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies · Ageing research reviews · 30 Sep 2026

2. Oxidative stress and ROS signalling induces mitochondrial dysfunction in humans.

   “Excessive production of reactive oxygen and nitrogen species, combined with declining antioxidant defenses, contributes to lipid peroxidation, mitochondrial dysfunction”

   Review

   From Retina to Vasculature: Oxidative Stress as a Common Mechanistic Link Between Age-Related Macular Degeneration and Cardiovascular Disease · Antioxidants (Basel, Switzerland) · 9 Sep 2026

Oxidative stress and ROS signalling →

1. Igf1 decreases mitochondrial dysfunction in mouse cells.

   “IGF-1 deficiency suppressed SLC25A33 expression in vitro, leading to mitochondrial ROS (mtROS) accumulation”

   CellsIGF-1 deficiency in vitropericyte

   IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026

Igf1 →

1. Epigenetic alterations increase mitochondrial dysfunction in humans.

   Reviewin chronic environmental exposuresbrain

   Neuroepigenetics of the Environmental Exposome: Molecular and Clinical Implications in Neurodegeneration · The neurologist · 28 Sep 2026

Epigenetic alterations →

1. SIRT1 protects against mitochondrial dysfunction.

   “SIRT1 maintains mitochondrial function through three interconnected pathways: PGC-1α-driven mitochondria biogenesis, FOXO-dependent antioxidant defense, and mitophagic clearance of damaged organelles.”

   Review

   SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026

SIRT1 →

1. Ceramides induce mitochondrial dysfunction in humans.

   Reviewcardiomyocyte

   Heart Failure: Lipid Metabolism Disorders Driving Cellular Senescence Through a Vicious Cycle, and Possible Intervention Strategies · Frontiers in bioscience (Landmark edition) · 1 Aug 2026

Ceramides →

1. Mitochondrial dysfunction is associated with type 2 diabetes in humans.

   Review

   Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies · Diabetes, metabolic syndrome and obesity : targets and therapy · 23 Sep 2026

2. Mitochondrial dysfunction is associated with type 2 diabetes in humans.

   “Mitochondrial dysfunction and impaired mitophagy remain fundamental, yet incompletely understood, mechanisms driving pancreatic β-cell failure, chronic inflammation, insulin resistance and diabetic complications.”

   Review

   Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective · Biomedicines · 24 Aug 2026

Type 2 diabetes →

1. Cellular senescence is associated with mitochondrial dysfunction in humans.

   Review

   Crosstalk between exosomes and cellular senescence: A core vicious loop promoting α-synuclein pathology in Parkinson's disease · Neural regeneration research · 30 Sep 2026

Cellular senescence →

1. Mitochondrial dysfunction is associated with age-related hearing loss.

   Reviewcochlea

   Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss · Molecular neurobiology · 30 Sep 2026

Age-related hearing loss →

1. TFAM is associated with mitochondrial dysfunction in human cells.

   CellsagingCD8-positive, alpha-beta T cell

   TFAM deficiency in T cells worsens viral lung pathology and weakens immunity · bioRxiv · 27 Sep 2026 · Preprint

TFAM →

1. Homo sapiens are associated with mitochondrial dysfunction in human cells.

   Cellsduring agingneuron

   Human neurons accumulate far more mutations over lifespan than shorter-lived mammals · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint

Homo sapiens →

1. Lipid and ceramide metabolism is associated with mitochondrial dysfunction.

   Reviewjoint

   Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation · Aging and disease · 23 Sep 2026

Lipid and ceramide metabolism →

1. Mitochondrial dysfunction is associated with dementia.

   Reviewin Alzheimer's disease

   Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies · Frontiers in molecular neuroscience · 15 Sep 2026

Dementia →

1. Mitochondrial dysfunction is associated with Parkinson's disease in humans.

   “Among these, mitochondrial dysfunction recurs across both familial and sporadic PD; however, this broad concept alone cannot explain disease heterogeneity.”

   Reviewacross both familial and sporadic PD

   Mitochondrial Quality Control Imbalance in the Heterogeneity of Parkinson's Disease: From Selective Vulnerability to Stratified Transformation · International journal of molecular sciences · 11 Sep 2026

Parkinson's disease →

1. Mitochondrial dysfunction raises the risk of aortic aneurysm in humans.

   “mitochondrial dysfunction plays a pivotal role in the initiation and progression of AAD.”

   Reviewaorta

   Mitochondrial dysfunction in aortic aneurysm and dissection: mechanisms and therapeutic implications · Frontiers in pharmacology · 10 Sep 2026

Aortic aneurysm →

1. Mitochondrial dysfunction raises the risk of chronic kidney disease in humans.

   “Growing evidence identifies oxidative stress and mitochondrial dysfunction as central drivers of renal injury and disease progression across diverse etiologies.”

   Reviewkidney

   Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease: From Molecular Mechanisms to Biomarkers and Targeted Therapies · Antioxidants (Basel, Switzerland) · 4 Sep 2026

Chronic kidney disease →