Saturday, 3 October 2026
Topic
Cognitive aging, neurodegeneration and the aging brain.
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
Food science & nutrition · Shi H et al.
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
bioRxiv · Yeewa R et al.
Systemic treatment activated liver AMPK, restored plasma metabolites, and enhanced dendritic spine maturation without altering hippocampal long-term potentiation.
Journal of neurochemistry · Nicol NI et al.
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
bioRxiv · R. Carvalho D et al.
Aged male mice showed far larger proteomic shifts than females following microglial removal, including alterations in synaptic and mitochondrial proteins.
bioRxiv : the preprint server for biology · Beganovic A et al.
Researchers identified a conserved neural progenitor pool that drives weekly brain regeneration in Botryllus schlosseri but collapses during aging.
bioRxiv : the preprint server for biology · Anselmi C et al.
Lysosomal multi-omics shows altered sphingolipid breakdown leads to glycosphingolipid buildup and lysosome enlargement, especially in aging microglia.
Cell reports · Sarkar C et al.
Spatial transcriptomics shows neuronal and vascular DNA damage responses correspond to distinct local cell neighborhoods in aging brains.
bioRxiv : the preprint server for biology · Koshboresh A et al.
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.
bioRxiv : the preprint server for biology · Bidhan V et al.
Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.
Research square · Kim H et al.
Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard hearing thresholds.
medRxiv : the preprint server for health sciences · Harris KC et al.
Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.
bioRxiv : the preprint server for biology · Caglayan E et al.
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
bioRxiv · Alsolami S et al.
The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.
Glia · Cimpean A et al.
A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.
Science advances · Hernandez H et al.
Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in older mice.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Huang L et al.
Treatment with astrocyte-conditioned solution also rescued cognitive deficits and lowered inflammation in mouse models of Alzheimer's disease.
bioRxiv · Vilademunt M et al.
Young flies housed alone showed faster retrovirus activation and more aggressive protein spread from glia to neurons.
bioRxiv · Murthygowda S et al.
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.
EMBO reports · Zhang T et al.
Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.
bioRxiv · Harris AS et al.
Researchers identified ghrelin as a key metabolic factor that reduces microglial senescence and inflammation through the SHBG/JNK1/Beclin1 signaling axis.
Aging cell · Zhou L et al.
The combined regimen lowered TMAO accumulation and suppressed inflammatory signaling more effectively than cognitive training alone.
Molecular neurobiology · Zhang R et al.
Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.
Alzheimer's & dementia : the journal of the Alzheimer's Association · Mostafaei S et al.
An immune risk score tracking immunosenescence correlated with markers of neural injury and neuroinflammation rather than classical amyloid or tau pathology.
Age and ageing · Luan H et al.
Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.
bioRxiv · Hagimori R et al.
Inactivating the ligase HOIL-1 solidifies dynamic protein condensates and impairs the autophagic clearance of tau, amyloid-beta, and alpha-synuclein aggregates.
The EMBO journal · Kaypee S et al.
Loss of the chaperone mediator in human astrocytes disrupts autophagy, proteasomes, and retromer traffic while impairing amyloid-beta proteostasis in neuron cocultures.
Proceedings of the National Academy of Sciences of the United States of America · Augur ZM et al.
A preprint shows SMPD1 upregulation collapses a sphingolipid salvage pathway, causing mitophagy defects and marking aggressive motor phenotypes.
bioRxiv · Rai S et al.
Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.
GeroScience · Diniz GB et al.