Fenofibrate

Intervention1 paper3 findingsPubChem 3339ChEBI 5001

Human trial1

Outcomes

Monocyte

downin mice1

1 study

Fenofibrate decreases monocyte in mice.
Animalsin chronic traumatic brain injurybrain parenchyma
Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate · Science translational medicine · 30 Sep 2026

Cognitive function

upin humans1

1 study

Fenofibrate improves cognitive function in humans.
Human trialin chronic traumatic brain injuryn = 40
Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate · Science translational medicine · 30 Sep 2026

NfL

downin humans1

1 study

Fenofibrate decreases NfL in humans.
Human trialin chronic traumatic brain injuryplasman = 40
Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate · Science translational medicine · 30 Sep 2026

NfL →

Latest

Human trialPeer-reviewedInflammaging1 Oct

Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate

Targeting PPARα deficiency in cranial bone marrow monocytes improved cognitive function and reduced neurodegeneration markers in older patients with chronic brain injury.

Science translational medicine · Lu Z et al.

Paper