Ghrelin
Intervention1 paper4 findingsPubChem 16133832ChEBI 75431MeSH D054439
- Animals1
Outcomes
4Shbg
downin mouse cells1
1 study
Shbg
downin mouse cells1
Ghrelin decreases Shbg in mouse cells.
“Sex hormone-binding globulin (SHBG) showed mainly cytoplasmic localization, was identified as a potential mediator of ghrelin signaling in microglia, and its expression was downregulated following ghrelin treatment.”
Cellsmicroglia
Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026
Chronic inflammation
downin mice1
1 study
Chronic inflammation
downin mice1
Ghrelin decreases chronic inflammation in mice.
“Ghrelin treatment improved cognitive function, attenuated microglial senescence, and suppressed inflammation”
Animals
Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
Ghrelin decreases cellular senescence in mice.
“Ghrelin treatment improved cognitive function, attenuated microglial senescence, and suppressed inflammation”
Animalsmicroglia
Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026
Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
Ghrelin improves cognitive function in mice.
“Ghrelin treatment improved cognitive function, attenuated microglial senescence, and suppressed inflammation”
Animals
Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026
Latest
1Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy
Researchers identified ghrelin as a key metabolic factor that reduces microglial senescence and inflammation through the SHBG/JNK1/Beclin1 signaling axis.
Aging cell · Zhou L et al.