Car-t cell therapy
Intervention1 paper2 findings
- Animals1
Outcomes
2Chronic inflammation
downin mice1
1 study
Chronic inflammation
downin mice1
Car-t cell therapy decreases chronic inflammation in mice.
Animalstargeting of aged inflammatory bone marrow myeloid progenitorsintravenous CAR T cellsbrain
CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice · bioRxiv · 28 Sep 2026 · Preprint
Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
Car-t cell therapy improves cognitive function in mice.
Animalsin mouse models of aging and Alzheimer's diseaseintrathecal CAR T cells targeting border-associated macrophages
CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice · bioRxiv · 28 Sep 2026 · Preprint
Latest
1CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice
Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.
bioRxiv · Harris AS et al.