Deregulated nutrient-sensing
Hallmark of aging40 papers
- Human trial1
- Humans1
- Animals9
- Model organisms10
- Cells1
Latest
40Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
bioRxiv · Yeewa R et al.
Neuropeptide signaling drives lipid breakdown during dietary restriction in roundworms
A relay involving sensory neurons, interneurons, and gut receptors coordinates fat mobilization when food intake drops.
bioRxiv : the preprint server for biology · Liu J et al.
Pan-AMPK activator MK-8722 improves spatial memory in Alzheimer's model mice
Systemic treatment activated liver AMPK, restored plasma metabolites, and enhanced dendritic spine maturation without altering hippocampal long-term potentiation.
Journal of neurochemistry · Nicol NI et al.
Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
bioRxiv · Olova NN et al.
Cysteine restriction extends lifespan and boosts metabolic fitness in animals
Reducing dietary cysteine independently of methionine enhanced survival in nematodes and reprogrammed the immunometabolic axis in mice.
bioRxiv : the preprint server for biology · Orliaguet L et al.
Dietary restriction activates autophagy through selective oxidation of ATG5
Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation in mice.
bioRxiv : the preprint server for biology · Shin S et al.
AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1
Experiments in human cells and computational modeling show that fasting sensor AMPK requires NAD+ and PGC-1-alpha to modulate cellular circadian rhythms.
bioRxiv · Vandenberghe A et al.
Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate
Targeting PPARα deficiency in cranial bone marrow monocytes improved cognitive function and reduced neurodegeneration markers in older patients with chronic brain injury.
Science translational medicine · Lu Z et al.