Saturday, 3 October 2026
Topic
Senescent cells, the SASP, and the drugs that clear or quiet them.
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Frontiers in pharmacology · Yang K et al.
Extended larval periods lowered lifetime reproductive success in Bugula neritina but reduced the rate of actuarial senescence in the field.
Evolution letters · Morgan W et al.
Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older females.
bioRxiv : the preprint server for biology · Skiles CM et al.
Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.
bioRxiv : the preprint server for biology · Correia J et al.
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
bioRxiv : the preprint server for biology · McCarthy EC et al.
In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular polarity.
bioRxiv : the preprint server for biology · Chen M et al.
Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.
RMD open · Jiménez-Martínez M et al.
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Neoplasia (New York, N.Y.) · Lin C et al.
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · Simpson DJ et al.
The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.
Nature metabolism · Koning M et al.
Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.
bioRxiv · Shabanian K et al.
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.
Biochimica et biophysica acta. General subjects · Xu J et al.
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chinese journal of natural medicines · Wang Y et al.
Blocking the cytokine with secukinumab reduced cartilage senescence and slowed osteoarthritis progression in a mouse model.
Oral diseases · Zhu M et al.
Combining pyroptosis-inducing Pd3Sn nanostructures with the senolytic piperlongumine targets treatment-induced senescent cells and reduces metastatic tumor burden in animal models.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Chen Z et al.
The synthetic particles deliver microRNAs and proteins to reduce senescence, lower fibrosis, and shift macrophages toward a pro-resolving state.
Biomaterials advances · Zhang L et al.
Physical activity preserved cardiac function and sustained FNDC5 and irisin signaling in mice exposed to doxorubicin.
Research Square · Jeyabal P et al.
The formulation co-delivers rapamycin and doxorubicin across the mucus barrier to inhibit mTOR and suppress tumor growth without evident systemic toxicity.
Biomaterials · Man Y et al.
Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.
Aging cell · Deng J et al.
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
bioRxiv · Torres G et al.
High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.
EMBO reports · Magnani E et al.
Analyses of human blood and plaque samples link KRAS-driven immunosenescence and cell cytotoxicity to early cardiovascular disease.
bioRxiv · Sun Z et al.
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.
Histology and histopathology · Hishida R et al.
Oral treatment restored bone density and mechanical strength while suppressing inflammatory markers and rebalancing intestinal bacteria in a disuse model.
Molecules (Basel, Switzerland) · Zhao X et al.
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.
Toxicology and applied pharmacology · Wang H et al.
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Guan X et al.
The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis.
Advanced materials (Deerfield Beach, Fla.) · Li X et al.
Silencing the upregulated gene PLXDC2 via brain-penetrating nanoparticles suppressed cGAS-STING signaling, reduced iron accumulation, and protected dopaminergic neurons.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Lu H et al.
Disrupted purine metabolism downstream of TDP43 dysfunction correlates with disease progression and drives cellular senescence in sporadic amyotrophic lateral sclerosis.
International journal of molecular sciences · Hall B et al.
Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · Huang YT et al.