MHY1485
Intervention1 paper1 findingPubChem 2834965
- Animals1
Outcomes
1Amyloid-beta 42
upin mice1
1 study
Amyloid-beta 42
upin mice1
MHY1485 increases amyloid-beta 42 in mice.
“pharmacological mTOR activation with MHY1485 further aggravated autophagic impairment and increased Aβ42 levels.”
Animalspharmacological mTOR activation
Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026
Latest
1AnimalsmTOR & rapamycin
Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1
Inhibiting mTORC1 restored autophagy, reduced amyloid accumulation, and corrected circuit desynchronization and behavioral deficits in stressed Alzheimer model mice.