PIEZO1 activation
Intervention1 paper1 finding
- Animals1
Outcomes
1Physical function
downin mice1
1 study
Physical function
downin mice1
PIEZO1 activation impairs physical function in mice.
Animalsin young micegut
Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice · bioRxiv : the preprint server for biology · 7 Sep 2026 · Preprint
Latest
1AnimalsPreprint
Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice
Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.