NKX2-5 overexpression
Intervention1 paper1 finding
- Animals1
Outcomes
1Transcriptomic age
downin mouse cells1
1 study
Transcriptomic age
downin mouse cells1
NKX2-5 overexpression decreases transcriptomic age in mouse cells.
Cells
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Latest
1AnimalsPreprint
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.