Saturday, 3 October 2026
Topic
Epigenetic, blood-based and other measures of biological age.
Culturing human neural, cardiac, and tonsil models in rotating-wall vessels for 24 hours also shifted contraction dynamics and immune gene expression.
bioRxiv · Mu W-C et al.
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
bioRxiv · Olova NN et al.
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
bioRxiv : the preprint server for biology · Vishnyakova O et al.
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Aging cell · Pyrgioti M et al.
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Genome medicine · Jonkman TH et al.
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.
Research Square · Na R et al.
Imperfect maintenance of developmental chromatin constraints causes age-associated DNA methylation gains predominantly at polycomb-regulated genomic regions across mammalian tissues.
Nature · Yücel AD et al.
The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.
bioRxiv · Goryanin I et al.
A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand participants.
Qeios · Xiong J
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.
medRxiv · Wu Q et al.
An analysis of NHANES data identifies source-dependent effects and an optimal serum iron window between 15.2 and 18.8 micromoles per liter.
Asia Pacific journal of clinical nutrition · Cao Q et al.
Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival.
Maturitas · Zhao H et al.
Researchers analyzed serial electrocardiograms from over 128,000 patients to distinguish cumulative cardiac aging damage from the rate of future electrical changes.
Journal of electrocardiology · Khalil ME et al.
Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark burdens.
bioRxiv · Schneider KL et al.
The computational approach identified reproducible conditional dependencies across two cohorts, highlighting stem cell maintenance and senescence regulation as broad markers of organ aging.
Preprints.org · Xiong J
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.
Aging and disease · Salech F et al.
A randomized trial shows a 12-month workout program slowed DNA methylation clocks and linked with preserved cognitive health.
Journal of the National Cancer Institute · Carlin D et al.
Researchers show that standard age-trained clocks reflect task-specific statistics rather than true biological aging constructs, limiting how researchers interpret clock gaps and rejuvenation.
bioRxiv · Song S et al.
Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging.
Alimentary pharmacology & therapeutics · Alsakarneh SG et al.
A large UK Biobank study finds vascular stiffness links to muscle loss, with accelerated biological age explaining part of the risk in non-frail adults.
Frontiers in public health · Sun A et al.
Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological coherence and predicts worse health outcomes.
medRxiv · Li Y et al.
Researchers analyzed UK Biobank data to identify causal circulating proteins that correlate with a refined metabolomic aging clock.
medRxiv · Luo X et al.
Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over 35.
medRxiv · Navarro-Flores A et al.
A convolutional neural network named ChromAgeNet distinguished young from aged mouse stem cells using three-dimensional nuclear images and identified key structural markers of aging.
Aging cell · Picazo PI et al.
In middle-aged adults, biological aging correlated with processing speed variability and baseline performance but did not predict cognitive change over time.
The journals of gerontology. Series A, Biological sciences and medical sciences · Zavala DV et al.