N-methyl-n-nitrosourea

Intervention1 paper3 findings

Cells1

Outcomes

Apoptosis

upin human cells1upin mouse cells1

1 study

N-methyl-n-nitrosourea induces apoptosis in mouse cells.
Cellsmesenchymal stem cell
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026
N-methyl-n-nitrosourea induces apoptosis in human cells.
Cellsmesenchymal stem cell
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026

Apoptosis →

PI3K–AKT signalling

downin N. xanthodon cells1

1 study

N-methyl-n-nitrosourea inhibits PI3K–AKT signalling in N. xanthodon cells.
Cellsfibroblast
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026

PI3K–AKT signalling →

Latest

CellsPeer-reviewed26 Sep

Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling

Unlike human and mouse cells, blind mole-rat stem cells maintained viability and differentiation after carcinogen exposure by preserving protective gene pathways.

Stem cells (Dayton, Ohio) · Unver N et al.

Paper