Hfn-gm@diplxdc2/dfo/ceo2-np
Intervention1 paper1 finding
- Animals1
Outcomes
1Motor performance
upin mice1
1 study
Motor performance
upin mice1
Hfn-gm@diplxdc2/dfo/ceo2-np improves motor performance in mice.
“Crucially, the treatment significantly alleviated dopaminergic neurodegeneration and improved motor performance-including coordination, balance, and endurance in PD mice.”
Animalsin PD mice
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Latest
1AnimalsCellular senescence
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice
Silencing the upregulated gene PLXDC2 via brain-penetrating nanoparticles suppressed cGAS-STING signaling, reduced iron accumulation, and protected dopaminergic neurons.