Vegfa deletion

Intervention1 paper2 findings

Outcomes

Aqueous humor outflow facility

downin mice1

1 study

Vegfa deletion decreases aqueous humor outflow facility in mice.
Animalsin CX3CR1+ macrophagesCX3CR1-Cre driven conditional knockoutocular angle
Macrophage-derived VEGFA helps maintain eye fluid pressure during aging · bioRxiv : the preprint server for biology · 11 Sep 2026 · Preprint

Intraocular pressure

upin mice1

1 study

Vegfa deletion increases intraocular pressure in mice.
Animalsin CX3CR1+ macrophagesCX3CR1-Cre driven conditional knockoutocular angle
Macrophage-derived VEGFA helps maintain eye fluid pressure during aging · bioRxiv : the preprint server for biology · 11 Sep 2026 · Preprint

AnimalsPreprint5 h

In aged mice and humans, macrophages cluster near Schlemm's canal to preserve aqueous humor outflow through compensatory growth factor signaling.

bioRxiv : the preprint server for biology · Kiyota N et al.