Nkx2-5δhd overexpression
Intervention1 paper3 findings
- Animals1
Outcomes
3Frailty
downin mice1
1 study
Frailty
downin mice1
Nkx2-5δhd overexpression decreases frailty in mice.
Animalssystemic delivery
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Grip strength
upin mice1
1 study
Grip strength
upin mice1
Nkx2-5δhd overexpression improves grip strength in mice.
Animalssystemic delivery
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Visual and electrophysiological function
upin mice1
1 study
Visual and electrophysiological function
upin mice1
Nkx2-5δhd overexpression improves visual and electrophysiological function in mice.
Animalssubretinal deliveryretina
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Latest
1Engineered cardiac transcription factor restores vision and reduces frailty in aging mice
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.
bioRxiv · Lu YRR et al.