Tnfa
Intervention1 paper2 findings
- Animals1
Outcomes
2Megakaryocyte
upin mice1
1 study
Megakaryocyte
upin mice1
Tnfa increases megakaryocyte in mice.
Animalscanonical hematopoietic hierarchy
Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice · bioRxiv · 29 Sep 2026 · Preprint
Hematopoietic stem and progenitor cell
upin mice1
1 study
Hematopoietic stem and progenitor cell
upin mice1
Tnfa increases hematopoietic stem and progenitor cell in mice.
Animalschronic exposurebone marrow
Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice · bioRxiv · 29 Sep 2026 · Preprint
Latest
1Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice
The inflammatory cytokine acts directly on stem cells rather than mature megakaryocytes, driving myeloid biasing and thromboinflammation through a persistent transcriptional program.
bioRxiv · Siner JI et al.