Spaceflight

Intervention2 papers6 findings

In silico studies link spaceflight to cellular senescence, chronic inflammation, elevated Igfbp1, and decreased Cry1 in female kidneys, alongside activation of Hdac7 and inhibition of Hsf1 in tibialis anterior muscle.

In silico2

Outcomes

Hdac7

upin silico1

1 study

Spaceflight activates Hdac7 in silico.
In silicotibialis anterior muscle
Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR · PloS one · 1 Oct 2026

Hdac7 →

Hsf1

downin silico1

1 study

Spaceflight inhibits Hsf1 in silico.
In silicotibialis anterior muscle
Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR · PloS one · 1 Oct 2026

Hsf1 →

Igfbp1

upin silico1

1 study

Spaceflight increases Igfbp1 in silico.
In silicoage-conservedkidney55–58 daysfemales
Spaceflight Is Associated with an Age-Conserved Kidney Transcriptomic Signature Linked to Inflammation, Tubular Channelopathy, and Senescence · Preprints.org · 29 Sep 2026 · Preprint

Igfbp1 →

Cry1

downin silico1

1 study

Spaceflight decreases Cry1 in silico.
In silicoage-conservedkidney55–58 daysfemales
Spaceflight Is Associated with an Age-Conserved Kidney Transcriptomic Signature Linked to Inflammation, Tubular Channelopathy, and Senescence · Preprints.org · 29 Sep 2026 · Preprint

Cry1 →

Associations

Chronic inflammation

upin silico1

1 study

Spaceflight is associated with chronic inflammation in silico.
In silicoage-conserved signaturekidney55–58 daysfemales
Spaceflight Is Associated with an Age-Conserved Kidney Transcriptomic Signature Linked to Inflammation, Tubular Channelopathy, and Senescence · Preprints.org · 29 Sep 2026 · Preprint

Chronic inflammation →

Cellular senescence

upin silico1

1 study

Spaceflight is associated with cellular senescence in silico.
In silicoage-conserved signaturekidney55–58 daysfemales
Spaceflight Is Associated with an Age-Conserved Kidney Transcriptomic Signature Linked to Inflammation, Tubular Channelopathy, and Senescence · Preprints.org · 29 Sep 2026 · Preprint

Cellular senescence →

Latest

Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR

In silicoPloS oneYesterday

Spaceflight Is Associated with an Age-Conserved Kidney Transcriptomic Signature Linked to Inflammation, Tubular Channelopathy, and Senescence

In silicoPreprintPreprints.org30 Sep