Compound 991
Intervention1 paper4 findings
- Model organisms1
Outcomes
2Lifespan
upin fission yeast1upin flies1upin worms1
1 study
Lifespan
upin fission yeast1upin flies1upin worms1
Compound 991 extends lifespan in fission yeast.
Model organisms
Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026
Compound 991 extends lifespan in worms.
Model organisms
Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026
Compound 991 extends lifespan in flies.
Model organisms
Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026
Pro-longevity proteomic profile
upin mice1
1 study
Pro-longevity proteomic profile
upin mice1
Compound 991 induces pro-longevity proteomic profile in mice.
Animals
Direct AMPK activation extends lifespan across yeast, worms, and flies · Aging cell · 30 Sep 2026
Latest
1Direct AMPK activation extends lifespan across yeast, worms, and flies
Treatment with the direct activator 991 also induced a pro-longevity proteomic profile in mice.
Aging cell · Dos Santos E et al.