Caloric restriction
Intervention5 papers6 findings
Reviews describe caloric restriction as extending lifespan and increasing corticosterone, whilst linking maternal restriction to anxiety-like behaviour. In mice, one study shows it increases cortical lipids with higher degrees of unsaturation.
- Animals3
- Model organisms1
Outcomes
4Lifespan
upin reviews3
3 studies
Lifespan
upin reviews3
Caloric restriction extends lifespan.
Review
Caloric restriction and neuropsychiatric phenotypes: A critical review of preclinical data · Neuroscience and biobehavioral reviews · 26 Sep 2026
Caloric restriction extends lifespan.
Review
Dietary restriction activates autophagy through selective oxidation of ATG5 · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint
Caloric restriction extends lifespan.
Review
Caloric restriction dynamically alters RNA splicing and lipid composition in mouse brains · bioRxiv · 22 Sep 2026 · Preprint
Anxiety-like behavior
upin reviews1
1 study
Anxiety-like behavior
upin reviews1
Caloric restriction induces anxiety-like behavior.
Reviewmaternal CR
Caloric restriction and neuropsychiatric phenotypes: A critical review of preclinical data · Neuroscience and biobehavioral reviews · 26 Sep 2026
Corticosterone
upin reviews1
1 study
Corticosterone
upin reviews1
Caloric restriction increases corticosterone.
Review
Caloric restriction and neuropsychiatric phenotypes: A critical review of preclinical data · Neuroscience and biobehavioral reviews · 26 Sep 2026
Lipids with higher degrees of unsaturation
upin mice1
1 study
Lipids with higher degrees of unsaturation
upin mice1
Caloric restriction increases lipids with higher degrees of unsaturation in mice.
Animalscortex
Caloric restriction dynamically alters RNA splicing and lipid composition in mouse brains · bioRxiv · 22 Sep 2026 · Preprint
Latest
9Neuropeptide signaling drives lipid breakdown during dietary restriction in roundworms
A relay involving sensory neurons, interneurons, and gut receptors coordinates fat mobilization when food intake drops.
bioRxiv : the preprint server for biology · Liu J et al.
Dietary restriction activates autophagy through selective oxidation of ATG5
Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation in mice.
bioRxiv : the preprint server for biology · Shin S et al.
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies
Depp1 drives muscle loss under fasting and low oxygen in mice
The study reveals that the protein localizes to mitochondria to regulate autophagy and mitochondrial degradation during nutrient and oxygen limitation.
bioRxiv · Qayyum S et al.
Neuroenergetic flexibility in the aging brain: Cellular mechanisms and diet-induced metabolic switching
Caloric restriction and neuropsychiatric phenotypes: A critical review of preclinical data
Caloric restriction dynamically alters RNA splicing and lipid composition in mouse brains
Researchers found that dietary restriction reshapes alternative splicing in an age-specific manner while driving coordinated changes in cortical brain lipids.
bioRxiv · Tye SA et al.