Endothelial mitochondria-targeted chemogenetic hydrogen sulfide

Intervention1 paper2 findings

Outcomes

Age-related pathology

downin mice1

1 study

Endothelial mitochondria-targeted chemogenetic hydrogen sulfide decreases age-related pathology in mice.
Animalsremote-control, endothelial-specific, mitochondria-targeted chemogenetic systemblood vessel
Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice · bioRxiv · 30 Sep 2026 · Preprint

Cellular senescence

downin mice1

1 study

Endothelial mitochondria-targeted chemogenetic hydrogen sulfide decreases cellular senescence in mice.
Animalsremote-control, endothelial-specific, mitochondria-targeted chemogenetic systemendothelial cell
Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice · bioRxiv · 30 Sep 2026 · Preprint

AnimalsPreprintCellular senescence1 Oct

Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.

bioRxiv · Shabanian K et al.