Senescence-associated secretory phenotype (SASP)
Pathway40 papers11 findings
In human and mouse cell models, varied chemical and genetic exposures activate or suppress the senescence-associated secretory phenotype. In a mouse study of pulmonary fibrosis, BAPTA-AM inhibits this phenotype, whilst reviews describe adverse cardiac effects and tumour progression.
- Human trial1
- Humans1
- Animals10
- Cells7
- In silico2
Interventions
5Bapta-am
downin mice1
1 study
Bapta-am
downin mice1
Bapta-am inhibits senescence-associated secretory phenotype (SASP) in mice.
Animalspulmonary fibrosislung
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis · Biochimica et biophysica acta. General subjects · 30 Sep 2026
Berberine
downin reviews1
1 study
Berberine
downin reviews1
Berberine decreases senescence-associated secretory phenotype (SASP).
Review
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026
Mitomycin c
upin human cells1
1 study
Mitomycin c
upin human cells1
Mitomycin c increases senescence-associated secretory phenotype (SASP) in human cells.
Cellsumbilical cord mesenchymal stem cell1.5 μg/mL7 days
Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C · Bulletin of experimental biology and medicine · 28 Sep 2026
Micro- and nanoplastics
upin human cells1
1 study
Micro- and nanoplastics
upin human cells1
Micro- and nanoplastics activate senescence-associated secretory phenotype (SASP) in human cells.
Cellsbrain organoid
Microplastics induce cellular senescence and alter network activity in human brain organoids · bioRxiv · 24 Sep 2026 · Preprint
Uqh 1,4-bis-hemi-succinate
downin human cells1
1 study
Uqh 1,4-bis-hemi-succinate
downin human cells1
Uqh 1,4-bis-hemi-succinate decreases senescence-associated secretory phenotype (SASP) in human cells.
Cellsesterified derivativedermal fibroblast100 μM48 h
Enhanced Extracellular Matrix Synthesis-Related Responses Induced by Ubiquinol-10 Derivatives in Human Dermal Fibroblasts · BioFactors (Oxford, England) · 1 Sep 2026
Effects
2Tumor progression
upin reviews1
1 study
Tumor progression
upin reviews1
Senescence-associated secretory phenotype (SASP) increases tumor progression.
Reviewin persistent senescent cells
Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications · Journal of hematology & oncology · 29 Sep 2026
Heart
downin humans1
1 study
Heart
downin humans1
Senescence-associated secretory phenotype (SASP) impairs heart in humans.
Reviewheart
Heart Failure: Lipid Metabolism Disorders Driving Cellular Senescence Through a Vicious Cycle, and Possible Intervention Strategies · Frontiers in bioscience (Landmark edition) · 1 Aug 2026
Upstream
2Ccnd2
upin mouse cells1
1 study
Ccnd2
upin mouse cells1
Ccnd2 increases senescence-associated secretory phenotype (SASP) in mouse cells.
Cellsmacrophage
A distinct p21-driven macrophage senotype accumulates during aging and liver disease · bioRxiv · 28 Sep 2026 · Preprint
cGAS–STING signalling
upin reviews1
1 study
cGAS–STING signalling
upin reviews1
cGAS–STING signalling induces senescence-associated secretory phenotype (SASP).
Reviewbrain
[Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging] · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 1 Jul 2026
Associations
1Cellular senescence
mixedin silico1upin reviews1
2 studies
Cellular senescence
mixedin silico1upin reviews1
Cellular senescence is associated with senescence-associated secretory phenotype (SASP) in silico.
“We also assessed the enrichment of antigen presentation pathways and the production of senescence-associated pro-inflammatory factors (SASP) in senescent cells across tissues.”
In silicon = 177
Senescent Cell Heterogeneity: Tissue-Dependent Signatures and Age Dynamics Revealed by Human scRNA-Seq Data · International journal of molecular sciences · 21 Sep 2026
Cellular senescence is associated with senescence-associated secretory phenotype (SASP).
Review
Pathogenic modulators of cellular senescence · Vavilovskii zhurnal genetiki i selektsii · 1 Sep 2026
Latest
41Senescent CD4 T cells drive age-associated autoimmunity in mice and humans
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
bioRxiv : the preprint server for biology · McCarthy EC et al.
Pathogenic modulators of cellular senescence
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Neoplasia (New York, N.Y.) · Lin C et al.
Crosstalk between exosomes and cellular senescence: A core vicious loop promoting α-synuclein pathology in Parkinson's disease
Enhanced Extracellular Matrix Synthesis-Related Responses Induced by Ubiquinol-10 Derivatives in Human Dermal Fibroblasts
Wound Healing, Senescence, and Senotherapeutics
Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chinese journal of natural medicines · Wang Y et al.
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.
Biochimica et biophysica acta. General subjects · Xu J et al.
Ultrasound-activated quantum biomaterial pairs with senolytic to suppress colorectal cancer
Combining pyroptosis-inducing Pd3Sn nanostructures with the senolytic piperlongumine targets treatment-induced senescent cells and reduces metastatic tumor burden in animal models.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Chen Z et al.