Saturday, 3 October 2026
Topic
Chronic low-grade inflammation and the aging immune system.
A Mendelian randomization analysis of 91 circulating inflammatory markers identified tumor necrosis factor-beta as causally linked to better muscle mass, grip strength, and walking pace.
Medicine · Mei Z et al.
Epicutaneous challenges in mice reveal context-dependent shifts in local immune cell recruitment rather than a uniform decline in tissue immunity.
bioRxiv : the preprint server for biology · Severn MM et al.
Researchers identified a transient senescent-like monocyte state governed by the transcription factor AP-1 that primes cells toward inflammatory and sepsis-associated states.
bioRxiv : the preprint server for biology · Vasilopoulos T et al.
Declining levels of the chromatin organizer SATB1 disrupt genomic boundaries and drive inflammatory gene activation in naive CD4+ T cells.
Science advances · Wang B et al.
A 12-month randomized trial showed greater drops in epicardial adipose volume with more weekly sessions alongside lower circulating M-CSF levels.
Frontiers in public health · Xue X et al.
Simulating age-related declines in disc Wnt signaling blunted chemotactic gene expression and cut injury-induced myeloid infiltration roughly in half.
Aging cell · Kroon TM et al.
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
bioRxiv · Yang L et al.
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
medRxiv · Zhao K et al.
Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.
Research Square · Liu Y et al.
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.
bioRxiv · Tan X et al.
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
medRxiv · Small A et al.
Vesicles fused from M2 macrophages and keratinocytes reduced oxidative stress, inflammation, and collagen degradation through the IL-4Rα/JAK/STAT3 pathway.
ACS applied materials & interfaces · Hao Y et al.
Depleting Camp accelerated bone callus formation in aged mice while delaying repair in young mice through P2X7 receptor and NLRP3 signaling.
bioRxiv · Nguyen T et al.
Targeting PPARα deficiency in cranial bone marrow monocytes improved cognitive function and reduced neurodegeneration markers in older patients with chronic brain injury.
Science translational medicine · Lu Z et al.
Single-cell profiling reveals distinct neutrophil subsets that promote senescence in vascular and liver cells while altering bone marrow progenitor states.
Aging cell · Wang Y et al.
Accumulated persistent corpora lutea and multinucleated giant cells create inflammatory focal hotspots that trigger tissue remodeling in mouse ovaries.
bioRxiv · Converse A et al.
The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after prolonged exposure.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Sharma PK et al.
A single-nucleus atlas reveals stem cell loss, altered sebocyte activity, and shifted immune interactions in the hair follicles of older men.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Li Y et al.
The inflammatory cytokine acts directly on stem cells rather than mature megakaryocytes, driving myeloid biasing and thromboinflammation through a persistent transcriptional program.
bioRxiv · Siner JI et al.
Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.
Bulletin of experimental biology and medicine · Blagova AV et al.
A conserved interferon-gamma signature and heightened T cell recruitment drive worse long-term heart failure outcomes in older mice following myocardial infarction.
Journal of molecular and cellular cardiology · Melika ET et al.
Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two national cohorts.
Maturitas · Liu ZY et al.
Researchers mapped signaling pathways between senescent-like immune cells and muscle stem cells across multiple human transcriptomic datasets.
International journal of molecular sciences · Liu X et al.
Clustering four age-associated inflammatory cytokines separated adults into three distinct endotypes tied to early chronic lung disease risk.
Journal of inflammation research · Wu B et al.