Lipid and ceramide metabolism
Pathway46 papers8 findings
In humans, lipid and ceramide metabolism correlates with cellular senescence in elderly COVID-19 patients and increases in aging male sebocytes, whilst reviews link it to steatosis, osteoarthritis, and mitochondrial dysfunction. In worms, nlp-10 regulates intestinal pathway activity under dietary restriction.
- Human trial1
- Humans6
- Animals12
- Model organisms16
- Cells3
Effects
2Steatosis
upin humans1
1 study
Steatosis
upin humans1
Lipid and ceramide metabolism induces steatosis in humans.
Reviewliver
Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder · Nature reviews. Nephrology · 24 Sep 2026
Osteoarthritis
upin reviews1
1 study
Osteoarthritis
upin reviews1
Lipid and ceramide metabolism induces osteoarthritis.
Reviewfor certain cholesterol and fatty acid pathwaysjoint
Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation · Aging and disease · 23 Sep 2026
Upstream
2nlp-10
is required forin worms1upin worms1
1 study
nlp-10
is required forin worms1upin worms1
nlp-10 is required for lipid and ceramide metabolism in worms.
Model organismsin diet-restricted mutants
Neuropeptide signaling drives lipid breakdown during dietary restriction in roundworms · bioRxiv : the preprint server for biology · 23 Sep 2026 · Preprint
nlp-10 increases lipid and ceramide metabolism in worms.
Model organismsunder chronic dietary restrictionintestine
Neuropeptide signaling drives lipid breakdown during dietary restriction in roundworms · bioRxiv : the preprint server for biology · 23 Sep 2026 · Preprint
Sebocyte
upin humans1
1 study
Sebocyte
upin humans1
Sebocyte increases lipid and ceramide metabolism in humans.
Humansduring agingpilosebaceous unitmales
Human vellus hair units undergo cellular and metabolic remodeling during skin aging · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 29 Sep 2026
Associations
2Cellular senescence
upin humans1upin reviews1
2 studies
Cellular senescence
upin humans1upin reviews1
Lipid and ceramide metabolism is associated with cellular senescence.
Reviewthrough dysregulation of organelles such as the endoplasmic reticulum and mitochondriajoint
Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation · Aging and disease · 23 Sep 2026
Lipid and ceramide metabolism is associated with cellular senescence in humans.
“Dysregulated plasma phospholipid metabolism, particularly involving phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), and lysophosphatidylethanolamine (LPE), was associated with T-cell senescence in elderly COVID-19 patients.”
Humanselderly COVID-19 patientsplasma
Plasma metabolic shifts link to T-cell senescence and mortality in older COVID-19 patients · Biomedicines · 19 Sep 2026
Mitochondrial dysfunction
upin reviews1
1 study
Mitochondrial dysfunction
upin reviews1
Lipid and ceramide metabolism is associated with mitochondrial dysfunction.
Reviewjoint
Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation · Aging and disease · 23 Sep 2026
Latest
46Aged human muscle secretes an enzyme that impairs stem cell maintenance
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
bioRxiv · Crisol B et al.
Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Frontiers in pharmacology · Yang K et al.
Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
bioRxiv · Yeewa R et al.
Neuropeptide signaling drives lipid breakdown during dietary restriction in roundworms
A relay involving sensory neurons, interneurons, and gut receptors coordinates fat mobilization when food intake drops.
bioRxiv : the preprint server for biology · Liu J et al.
Pan-AMPK activator MK-8722 improves spatial memory in Alzheimer's model mice
Systemic treatment activated liver AMPK, restored plasma metabolites, and enhanced dendritic spine maturation without altering hippocampal long-term potentiation.
Journal of neurochemistry · Nicol NI et al.
Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
bioRxiv · Olova NN et al.
Aging mouse brains accumulate myelin lipids that drive lysosomal dysfunction
Lysosomal multi-omics shows altered sphingolipid breakdown leads to glycosphingolipid buildup and lysosome enlargement, especially in aging microglia.
Cell reports · Sarkar C et al.
Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants
Fruit flies provide an in vivo model to study ferroptosis and lifespan
Ferroptosis-inducing compounds shortened fly lifespan in a diet-dependent manner, while antioxidant treatment restored longevity and reversed iron-related changes in males.
Redox biology · Zhang L et al.
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
Cell reports · Matsumoto S et al.