Oxidative stress and ROS signalling

1. Ginsenosides decrease oxidative stress and ROS signalling.

   Review

   Traditional Chinese medicine-derived natural products and formulations as pharmacological modulators of ageing-related pathways: mechanisms and therapeutic potential · The Journal of pharmacy and pharmacology · 1 Oct 2026

Ginsenosides →

1. 4-octyl itaconate decreases oxidative stress and ROS signalling in mice.

   Animalsparotid gland25 mg/kg4 weeksmales

   4-Octyl itaconate restores parotid gland function in aging mice · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 30 Sep 2026

4-octyl itaconate →

1. Apigenin decreases oxidative stress and ROS signalling in worms.

   Model organisms

   Apigenin Improves Healthspan and Protects Against Alzheimer's Disease-Associated Proteotoxicity in C. elegans · bioRxiv · 29 Sep 2026 · Preprint

Apigenin →

1. Dha deficiency induces oxidative stress and ROS signalling in mice.

   Animalschronicneural retina

   Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice · bioRxiv · 28 Sep 2026 · Preprint

Dha deficiency →

1. SEPHIN1 decreases oxidative stress and ROS signalling in human cells.

   Cellsin PFFs-stimulated cells

   Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026

SEPHIN1 →

1. Berberine decreases oxidative stress and ROS signalling.

   Review

   Berberine induces pleiotropic beneficial effects via hormesis · Pharmacological research · 25 Sep 2026

Berberine →

1. Telomir-zn decreases oxidative stress and ROS signalling in zebrafish.

   “Telomir-Zn reduced oxidative stress, preserved retinal architecture, improved visual behaviors”

   Animalsin Sen57 wrn-/- ND6-/+ zebrafishretina

   Targeted metal modulation preserves retinal structure and vision in zebrafish · International journal of molecular sciences · 16 Sep 2026

Telomir-zn →

1. Bifidobacterium animalis subsp. lactis protects against oxidative stress and ROS signalling in human cells.

   “BL-G101 treatment also protects against UVB-induced oxidative stress, which was evidenced by significantly decreased MDA levels and enhanced SOD activity.”

   Cellsunder UVB exposureBL-G101Hs68

   Bifidobacterium animalis subsp. lactis BL-G101 Protects Against UVB-Induced Photoaging in HS68 Dermal Fibroblasts · Nutrients · 15 Sep 2026

Bifidobacterium animalis subsp. lactis →

1. Palmitoylethanolamide + luteolin decreases oxidative stress and ROS signalling.

   “Preclinical studies suggest that PEA-Lut may attenuate glial activation, pro-inflammatory signaling, oxidative and nitrosative stress, and amyloid-β-induced cellular injury”

   Reviewco-ultramicronized

   Palmitoylethanolamide and Luteolin in Brain Aging and Cognitive Decline: Biological Rationale and Current Evidence · Nutrients · 9 Sep 2026

Palmitoylethanolamide + luteolin →

1. Cornus officinalis decreases oxidative stress and ROS signalling.

   Review

   Cornus officinalis Fruit in the Modulation of Aging-Related Cellular Pathways: a short review · Journal of pharmacopuncture · 1 Sep 2026

Cornus officinalis →

1. Oxidative stress and ROS signalling induces mitochondrial dysfunction.

   Review

   Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies · Ageing research reviews · 30 Sep 2026

2. Oxidative stress and ROS signalling induces mitochondrial dysfunction in humans.

   “Excessive production of reactive oxygen and nitrogen species, combined with declining antioxidant defenses, contributes to lipid peroxidation, mitochondrial dysfunction”

   Review

   From Retina to Vasculature: Oxidative Stress as a Common Mechanistic Link Between Age-Related Macular Degeneration and Cardiovascular Disease · Antioxidants (Basel, Switzerland) · 9 Sep 2026

Mitochondrial dysfunction →

1. Oxidative stress and ROS signalling decreases endocochlear-potential reserve.

   Reviewstria vascularis

   Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss · Molecular neurobiology · 30 Sep 2026

1. Oxidative stress and ROS signalling induces genomic instability.

   “Excessive ROS/RNS trigger irreversible DNA damage and metabolic disorders, leading to inflammation and apoptosis.”

   Reviewexcessive ROS/RNS

   Oxidative Stress in Animals: A Systematic Analysis from Signaling Pathways to Biological Effects · Life (Basel, Switzerland) · 11 Sep 2026

Genomic instability →

1. klf-1 is required for oxidative stress and ROS signalling in worms.

   Model organismsin germline-deficient animals

   Krüppel-like factors modulate SKN-1 activity and lipid balance to control worm lifespan · Genetics · 29 Sep 2026

klf-1 →

1. Acomys protect against oxidative stress and ROS signalling in Acomys cells.

   Cellsear pinna fibroblast

   Spiny mouse fibroblasts prefer glycolysis and resist oxidative stress across lifespan · The Journal of biological chemistry · 24 Sep 2026

Acomys →

1. Oxidative stress and ROS signalling is associated with age-related macular degeneration in humans.

   “oxidative stress has emerged as one of the most plausible links connecting retinal degeneration and cardiovascular pathology.”

   Reviewretina

   From Retina to Vasculature: Oxidative Stress as a Common Mechanistic Link Between Age-Related Macular Degeneration and Cardiovascular Disease · Antioxidants (Basel, Switzerland) · 9 Sep 2026

Age-related macular degeneration →