Parthenolide
Intervention1 paper2 findingsPubChem 6473881ChEBI 181553MeSH C002669
- Animals1
Outcomes
2Localized scleroderma
downin mice1
1 study
Localized scleroderma
downin mice1
Parthenolide protects against localized scleroderma in mice.
AnimalsF127@PLGA@PTL hydrogel
Parthenolide reduces senescence and skin fibrosis in scleroderma models · Aging cell · 30 Sep 2026
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Parthenolide decreases cellular senescence in human cells.
CellsTGF-β-induceddermal fibroblast
Parthenolide reduces senescence and skin fibrosis in scleroderma models · Aging cell · 30 Sep 2026
Latest
1Parthenolide reduces senescence and skin fibrosis in scleroderma models
The compound targets Ero1L to stabilize contacts between mitochondria and the endoplasmic reticulum, mitigating tissue damage in cells and mice.
Aging cell · Wang F et al.