Cellular senescence

1. Exercise decreases cellular senescence in mice.

   Animalsdoxorubicin treatmentheart

   Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence · Research Square · 29 Sep 2026 · Preprint

2. Exercise decreases cellular senescence.

   Review

   Integrated Multi-Omics Network by Physical Exercise Across Aging: Molecular Adaptation Beyond Single Signaling Pathways · Physiological genomics · 21 Sep 2026

Exercise →

1. Rapamycin inhibits cellular senescence in human cells.

   Cellsepithelial cell

   Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint

2. Rapamycin decreases cellular senescence in mice.

   Animalstherapy-induced senescence in chemoresistant lung cancertumor

   Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026

Rapamycin →

1. GFD-CD3 bite decreases cellular senescence in non-human primates.

   “low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”

   Animalsat low doselow-dose

   Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026

2. GFD-CD3 bite decreases cellular senescence in mice.

   “low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”

   Animalsat low doselow-dose

   Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026

GFD-CD3 bite →

1. GSK2656157 decreases cellular senescence in human cells.

   Cellsin ALI-cultured HBECs from severe asthmatic donorshuman bronchial epithelial cell

   Loss of PP4 drives airway senescence through endoplasmic reticulum stress · Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 27 Sep 2026

2. GSK2656157 decreases cellular senescence in mice.

   Animalsin HDM-induced asthma modelairway epithelial cell

   Loss of PP4 drives airway senescence through endoplasmic reticulum stress · Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 27 Sep 2026

GSK2656157 →

1. Pten knockout induces cellular senescence in mice.

   Animalsprostate-specific conditional knockoutprostatemales

   Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling · Neoplasia (New York, N.Y.) · 1 Oct 2026

Pten knockout →

1. Dasatinib + quercetin decreases cellular senescence in humans.

   Human trialfibrotic MASHliverdasatinib 100 mg per day plus quercetin 1,000 mg per daythree consecutive days per week over 3 weeks, repeated across three 7-week cycles

   Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial · Nature metabolism · 1 Oct 2026

Dasatinib + quercetin →

1. Syringin decreases cellular senescence in mice.

   Animalsbleomycin-induced pulmonary fibrosislung

   Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models · Chinese journal of natural medicines · 1 Oct 2026

Syringin →

1. M2-KC-FEV decreases cellular senescence in mouse cells.

   Cellsin UVB-injured mouse keratinocytes and dermal fibroblasts

   Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging · ACS applied materials & interfaces · 1 Oct 2026

M2-KC-FEV →

1. Endothelial mitochondria-targeted chemogenetic hydrogen sulfide decreases cellular senescence in mice.

   Animalsremote-control, endothelial-specific, mitochondria-targeted chemogenetic systemendothelial cell

   Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice · bioRxiv · 30 Sep 2026 · Preprint

Endothelial mitochondria-targeted chemogenetic hydrogen sulfide →

1. Bapta-am decreases cellular senescence in mouse cells.

   Cellssenescence stimulifibroblast

   Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis · Biochimica et biophysica acta. General subjects · 30 Sep 2026

Bapta-am →

1. Cellular senescence increases skin.

   Reviewfollowing damage and with advancing ageskin

   Wound Healing, Senescence, and Senotherapeutics · Advances in wound care · 30 Sep 2026

1. Cellular senescence impairs mesenchymal stem cell.

   Review

   Clinical Translation of Mesenchymal Stem Cells to Medicinal Signaling Cells: Origins, Clinical Applications, and the Future of Regenerative Medicine-2026 Arnold I. Caplan Award for Distinguished Research in Orthobiologics · The Journal of the American Academy of Orthopaedic Surgeons · 30 Sep 2026

1. Cellular senescence decreases tumor growth.

   Reviewby inducing stable cell-cycle arrest and promoting immune clearance

   Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications · Journal of hematology & oncology · 29 Sep 2026

Tumor growth →

1. Cellular senescence increases tissue dysfunction.

   Review

   Artificial intelligence and in silico discovery of senolytic and senescence-associated food peptides · Food chemistry · 25 Sep 2026

1. Cellular senescence increases monocyte in humans.

   Humansduring human agingmonocyte

   Transitional senescent monocytes drive age-related inflammation in humans · bioRxiv : the preprint server for biology · 13 Sep 2026 · Preprint

1. Cellular senescence decreases ATP in human cells.

   “medium from senescent astrocytes failed to elicit this response and instead promoted hydrogen peroxide accumulation, ATP depletion and reduced cellular metabolic activity”

   Cellsconditioned medium from senescent astrocytes applied to neuronsneuron

   Senescent human astrocytes impair neuronal mitochondrial function through released factors · Antioxidants (Basel, Switzerland) · 6 Sep 2026

ATP →

1. Cellular senescence increases hydrogen peroxide in human cells.

   “medium from senescent astrocytes failed to elicit this response and instead promoted hydrogen peroxide accumulation, ATP depletion and reduced cellular metabolic activity”

   Cellsconditioned medium from senescent astrocytes applied to neuronsneuron

   Senescent human astrocytes impair neuronal mitochondrial function through released factors · Antioxidants (Basel, Switzerland) · 6 Sep 2026

Hydrogen peroxide →

1. Cellular senescence decreases mitochondrial membrane potential in human cells.

   “these cells displayed reduced mitochondrial membrane potential, intracellular ATP and cellular metabolic activity, indicating accumulation of a functionally impaired mitochondrial population.”

   Cellsin senescent astrocytesastrocyte

   Senescent human astrocytes impair neuronal mitochondrial function through released factors · Antioxidants (Basel, Switzerland) · 6 Sep 2026

Mitochondrial membrane potential →

1. Cellular senescence impairs fertility in humans.

   Reviewreproductive systemfemales

   The Possibility and Characteristics of Senescence-Related Changes in Reproductive Tissues Such as the Ovary, Oviduct, and Uterus · Reproductive medicine and biology · 1 Jan 2026

1. Mitochondrial dysfunction induces cellular senescence.

   Review

   Mitochondria and associated complexes as therapeutic targets in aging: From biomacromolecular structure-function insights to clinical translation · Mitochondrion · 1 Oct 2026

2. Mitochondrial dysfunction induces cellular senescence in humans.

   “These interconnected processes promote vascular smooth muscle cell (VSMC) phenotypic switching, apoptosis, and senescence”

   Reviewvascular smooth muscle cell

   Mitochondrial dysfunction in aortic aneurysm and dissection: mechanisms and therapeutic implications · Frontiers in pharmacology · 10 Sep 2026

Mitochondrial dysfunction →

1. Renovascular disease induces cellular senescence.

   Reviewkidney

   Renovascular Disease and Its Impact on Endogenous Kidney Repair: Stem/Progenitor Cells · Stem cells international · 30 Sep 2026

Renovascular disease →

1. Neutrophil induces cellular senescence in mouse cells.

   Cellsexposure to conditioned media from aged neutrophils or IL-6-stimulated neutrophil-like cellsvascular smooth muscle and hepatocyte-derived cells

   Aging remodels mouse neutrophils across organs to drive inflammatory and senescence responses · Aging cell · 30 Sep 2026

1. Upper gastrointestinal cancer increases cellular senescence in humans.

   Humanscompared to healthy controlssenescent CD8-positive, alpha-beta T cell

   Investigating immunological, transcriptomic and metabolomic signatures and their association with pneumonia after upper gastrointestinal cancer surgery · Research Square · 29 Sep 2026 · Preprint

Upper gastrointestinal cancer →

1. tp53 is required for cellular senescence in zebrafish.

   Animalsfor UHRF1 overexpression-induced senescencehepatocyte

   UHRF1 levels drive distinct senescent states in zebrafish liver cells · EMBO reports · 28 Sep 2026

tp53 →

1. Plxdc2 increases cellular senescence in mice.

   “Mechanistically, we demonstrate that PLXDC2 contributes to microglial senescence via the cGAS-STING pathway, and its silencing attenuates neuroinflammation and oxidative stress.”

   Animalsvia cGAS-STING pathwaymicroglia

   Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

Plxdc2 →

1. Fibroblast induces cellular senescence in human cells.

   Cellsconditioned media from older female fibroblasts at 7d-recoveryskeletal muscle7 days recoveryfemales

   Altered cell communication impairs muscle recovery in older women after disuse · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint

1. Genomic instability induces cellular senescence.

   “When these protective mechanisms fail, persistent DNA damage can promote apoptosis or senescence, alter inflammatory signaling and extracellular communication”

   Reviewwhen protective mechanisms failmacrophage

   Genomic Stress and DNA Repair During Macrophage Differentiation and Inflammatory Activation · International journal of molecular sciences · 17 Sep 2026

Genomic instability →

1. SIRT1 decreases cellular senescence.

   “SIRT1 levels and activity fall with age, and this decline directly promotes senescence.”

   Review

   SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026

SIRT1 →

1. bile acids increase cellular senescence in humans.

   Reviewdysregulated signalingliver

   Bile acids as a "new hormone" in aging-related liver disease · Life medicine · 7 Aug 2026

1. Cellular senescence is associated with senescence-associated secretory phenotype.

   Review

   Generative Molecular Design for Senescence-Associated Secretory Phenotype (SASP) Reversal: A REINVENT4 Pipeline Trained on Real LINCS L1000 Transcriptomic Data · Research Square · 29 Sep 2026 · Preprint

2. Cellular senescence is associated with senescence-associated secretory phenotype (SASP) in silico.

   “We also assessed the enrichment of antigen presentation pathways and the production of senescence-associated pro-inflammatory factors (SASP) in senescent cells across tissues.”

   In silicon = 177

   Senescent Cell Heterogeneity: Tissue-Dependent Signatures and Age Dynamics Revealed by Human scRNA-Seq Data · International journal of molecular sciences · 21 Sep 2026

3. Cellular senescence is associated with senescence-associated secretory phenotype (SASP).

   Review

   Pathogenic modulators of cellular senescence · Vavilovskii zhurnal genetiki i selektsii · 1 Sep 2026

Senescence-associated secretory phenotype (SASP) →

1. Lipid and ceramide metabolism is associated with cellular senescence.

   Reviewthrough dysregulation of organelles such as the endoplasmic reticulum and mitochondriajoint

   Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation · Aging and disease · 23 Sep 2026

2. Lipid and ceramide metabolism is associated with cellular senescence in humans.

   “Dysregulated plasma phospholipid metabolism, particularly involving phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), and lysophosphatidylethanolamine (LPE), was associated with T-cell senescence in elderly COVID-19 patients.”

   Humanselderly COVID-19 patientsplasma

   Plasma metabolic shifts link to T-cell senescence and mortality in older COVID-19 patients · Biomedicines · 19 Sep 2026

Lipid and ceramide metabolism →

1. Cellular senescence is associated with mitochondrial dysfunction in humans.

   Review

   Crosstalk between exosomes and cellular senescence: A core vicious loop promoting α-synuclein pathology in Parkinson's disease · Neural regeneration research · 30 Sep 2026

Mitochondrial dysfunction →

1. Hydrogen sulfide is associated with cellular senescence.

   Reviewendothelial cell

   Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice · bioRxiv · 30 Sep 2026 · Preprint

Hydrogen sulfide →

1. Spaceflight is associated with cellular senescence in silico.

   In silicoage-conserved signaturekidney55–58 daysfemales

   Spaceflight Is Associated with an Age-Conserved Kidney Transcriptomic Signature Linked to Inflammation, Tubular Channelopathy, and Senescence · Preprints.org · 29 Sep 2026 · Preprint

Spaceflight →

1. Cellular senescence is associated with chronic inflammation in humans.

   “while senescent mesenchymal cells may amplify inflammation via SASP.”

   Reviewin oral lichen planus (OLP)oral mucosa

   T-cell senescence and immunosenescence in chronic oral mucosal inflammatory diseases: mechanisms and therapeutic implications · Journal of oral microbiology · 27 Sep 2026

Chronic inflammation →

1. cGAS–STING signalling is associated with cellular senescence in humans.

   Reviewassociated with stress granule biology

   Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation · Molecular biology reports · 25 Sep 2026

cGAS–STING signalling →

1. Radiation-induced chronic wounds are associated with cellular senescence.

   “they arise from a self-perpetuating pathological cascade involving DNA damage, oxidative stress, chronic inflammation, microvascular dysfunction, cellular senescence, stem cell impairment, and fibrosis.”

   Review

   Chronic Radiation-Induced Wounds: Pathogenesis, Current Therapeutic Strategies, and Emerging Regenerative Approaches · International journal of molecular sciences · 15 Sep 2026

Radiation-induced chronic wounds →

1. Cellular senescence is associated with liver.

   Reviewphysiological agingliver

   Cell Senescence and the Aging Liver · Frontiers in bioscience (Landmark edition) · 1 Sep 2026