High-fat diet
Intervention3 papers3 findings
- Animals3
Outcomes
3Ubiquitinated mitochondrial proteins
upin mice1
1 study
Ubiquitinated mitochondrial proteins
upin mice1
High-fat diet increases ubiquitinated mitochondrial proteins in mice.
Animalscombined with chronic nitric oxide synthase inhibition (L-NAME) in aged micecardiomyocyte
Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction · American journal of physiology. Heart and circulatory physiology · 19 Sep 2026
Loss of proteostasis
upin mice1
1 study
Loss of proteostasis
upin mice1
High-fat diet increases loss of proteostasis in mice.
Animalscombined with chronic nitric oxide synthase inhibition (L-NAME) in aged micecardiomyocyte
Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction · American journal of physiology. Heart and circulatory physiology · 19 Sep 2026
Mitochondrial dysfunction
upin mice1
1 study
Mitochondrial dysfunction
upin mice1
High-fat diet increases mitochondrial dysfunction in mice.
Animalscombined with chronic nitric oxide synthase inhibition (L-NAME) in aged miceleft ventricular muscle
Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction · American journal of physiology. Heart and circulatory physiology · 19 Sep 2026
Latest
3Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.
Aging cell · Yang K et al.