Saturday, 3 October 2026
Topic
Nutrient sensing through mTOR, and the rapalogs that dial it down.
While lifelong depletion reduced muscle strength, short-term deficiency in adult mice induced hypertrophy without degrading muscle quality or contractile performance.
bioRxiv : the preprint server for biology · Son W et al.
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.
Research Square · Liu M et al.
Inhibiting mTORC1 restored autophagy, reduced amyloid accumulation, and corrected circuit desynchronization and behavioral deficits in stressed Alzheimer model mice.
CNS neuroscience & therapeutics · Zou Y et al.
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.
Aging cell · Qin M et al.