PDK4 inhibitor
Intervention1 paper1 finding
- Animals1
Outcomes
1Age-related pathology
downin mice1
1 study
Age-related pathology
downin mice1
PDK4 inhibitor decreases age-related pathology in mice.
“Pharmacological inhibition of PDK4 in vivo effectively ameliorates the age-related pathologies induced by hepatocyte-specific GHR ablation.”
Animalsin hepatocyte-specific GHR ablation mice
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026
Latest
1AnimalsMitochondria
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.