Autophagy

1. Coenzyme Q10 activates autophagy in mice.

   “Changes in the LC3-II/LC3-I ratio and p62 in bone marrow MKs were consistent with enhanced autophagy.”

   Animalsaged micemegakaryocyte12 weeksmales

   Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice · Aging cell · 30 Sep 2026

Coenzyme Q10 →

1. Chronic restraint stress inhibits autophagy in mice.

   “Mechanistically, transcriptomic profiling and biochemical validation revealed that chronic stress suppresses autophagic pathways via selective hyperactivation of mTORC1 signaling rather than the AMPK pathway.”

   Animalsvia selective hyperactivation of mTORC1 signaling

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

Chronic restraint stress →

1. Alpha-synuclein inhibits autophagy in mouse cells.

   “Mechanistically, α-Syn promoted macrophage foam cell formation by impairing autophagic flux, accompanied by activation of PI3K-mTOR signaling.”

   Cellsmacrophage

   Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026

Alpha-synuclein →

1. Berberine activates autophagy.

   Review

   Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026

Berberine →

1. BAG3 knockout decreases autophagy in human cells.

   Cellsin BAG3-deficient astrocytesCRISPR/Cas9 editingastrocyte

   Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease · Proceedings of the National Academy of Sciences of the United States of America · 28 Sep 2026

BAG3 knockout →

1. Leptin activates autophagy in pig cells.

   Cellsunder heat stressSertoli cellmales

   Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling · Journal of animal science · 26 Sep 2026

Leptin →

1. Arc-engineered exosomes activate autophagy.

   Animalsneural stem cell-derived exosomes overexpressing Arc

   Intranasal Arc-engineered exosomes reduce Alzheimer pathology by restoring autophagy · Nanomedicine : nanotechnology, biology, and medicine · 25 Sep 2026

Arc-engineered exosomes →

1. Exercise improves autophagy.

   Reviewin sarcopenic obesity

   Autophagy in sarcopenic obesity: muscle-adipose crosstalk, metabolic regulation, and exercise-based interventions · Metabolism: clinical and experimental · 24 Sep 2026

Exercise →

1. Rapamycin activates autophagy in mice.

   Animalstumor

   Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026

Rapamycin →

1. Nuciferine activates autophagy in rats.

   “it increased the microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I ratio and decreased p62 expression, as determined through Western blotting, indicating the activation of autophagy.”

   Animalsovariectomybone12 weeksfemales

   Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy · Biomolecules · 21 Sep 2026

Nuciferine →

1. SQSTM1 mediates autophagy.

   Review

   Sequestosome 1 (SQSTM1/p62) at the nexus of genome integrity maintenance, proteostasis regulation and organellar homeostasis · Biological chemistry · 28 Sep 2026

SQSTM1 →

1. Depp1 is required for autophagy in mice.

   Animalsskeletal muscle

   Depp1 drives muscle loss under fasting and low oxygen in mice · bioRxiv · 27 Sep 2026 · Preprint

Depp1 →

1. Atg5 is required for autophagy in mice.

   Animalsupon nutrient restriction, via Cys19 oxidation

   Dietary restriction activates autophagy through selective oxidation of ATG5 · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint

Atg5 →

1. ATG5 is required for autophagy in human cells.

   Cellsupon nutrient restriction, via Cys19 oxidation

   Dietary restriction activates autophagy through selective oxidation of ATG5 · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint

ATG5 →

1. acox-1.2 is required for autophagy in worms.

   “the increases in autophagy and lifespan observed in long-lived rsks-1(ok1255) mutants were suppressed by acox-1.2 RNAi.”

   Model organismsfor increased autophagy in rsks-1(ok1255) mutants

   Peroxisomal enzyme ACOX-1.2 enables extended lifespan in long-lived roundworms · Current issues in molecular biology · 4 Sep 2026

acox-1.2 →

1. Autophagy is associated with stem cell renewal in H. vulgaris.

   “sustained telomerase activity, autophagy regulation, and microbiome stability in H. vulgaris are associated with stem cell renewal and long-term tissue homeostasis”

   Review

   Conditional Senescence and Longevity Mechanisms in Early-Branching Metazoans: Insights from Hydra · Current issues in molecular biology · 19 Sep 2026