GSK2656157
Intervention1 paper2 findingsPubChem 53469059ChEBI 139047
- Cells1
Outcomes
1Cellular senescence
downin human cells1downin mice1
1 study
Cellular senescence
downin human cells1downin mice1
GSK2656157 decreases cellular senescence in human cells.
Cellsin ALI-cultured HBECs from severe asthmatic donorshuman bronchial epithelial cell
Loss of PP4 drives airway senescence through endoplasmic reticulum stress · Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 27 Sep 2026
GSK2656157 decreases cellular senescence in mice.
Animalsin HDM-induced asthma modelairway epithelial cell
Loss of PP4 drives airway senescence through endoplasmic reticulum stress · Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 27 Sep 2026
Latest
1Loss of PP4 drives airway senescence through endoplasmic reticulum stress
Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · Huang YT et al.