Huntingtin aggregate-responsive autophagy gene circuit
Intervention1 paper4 findings
- Animals1
Outcomes
4Lifespan
upin mice1
1 study
Lifespan
upin mice1
Huntingtin aggregate-responsive autophagy gene circuit extends lifespan in mice.
“This closed-loop intervention improves motor function and extends lifespan.”
Animalsin R6/2 HD mouse modelplasmid encapsulated in CD98-targeted immunoliposomes
Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Motor function
upin mice1
1 study
Motor function
upin mice1
Huntingtin aggregate-responsive autophagy gene circuit improves motor function in mice.
“This closed-loop intervention improves motor function and extends lifespan.”
Animalsin R6/2 HD mouse modelplasmid encapsulated in CD98-targeted immunoliposomes
Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Chronic inflammation
downin mice1
1 study
Chronic inflammation
downin mice1
Huntingtin aggregate-responsive autophagy gene circuit decreases chronic inflammation in mice.
“In the R6/2 HD mouse model, ARAA treatment significantly reduces mHTT burden, attenuates neuroinflammation, and rescues synaptic deficits.”
Animalsin R6/2 HD mouse modelplasmid encapsulated in CD98-targeted immunoliposomes
Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Mutant huntingtin
downin mice1
1 study
Mutant huntingtin
downin mice1
Huntingtin aggregate-responsive autophagy gene circuit decreases mutant huntingtin in mice.
“In the R6/2 HD mouse model, ARAA treatment significantly reduces mHTT burden, attenuates neuroinflammation, and rescues synaptic deficits.”
Animalsin R6/2 HD mouse modelplasmid encapsulated in CD98-targeted immunoliposomes
Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Latest
1Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice
The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic deficits.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Zhu J et al.