From ClinicalTrials.gov

Clinical trials

Trials of drugs and interventions aimed at aging, of age-related conditions through aging biology, and of healthspan itself: new registrations, status changes and first results.

ObservationalRecruitingAging biomarker

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Healthy Volunteers, Non-Healthy/Non-Frail, Frail

National Institute on Aging (NIA) · 900 planned · NCT02339012 · updated 2 Oct 2026

RecruitingGeroscience intervention

Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial

Urolithin A in Healthy Volunteer

National Institute on Aging (NIA) · 180 planned · NCT06274749 · updated 2 Oct 2026

Phase 2Active, not recruitingGeroscience intervention

Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD

Nicotinamide riboside in Vascular Diseases, Kidney Disease, Blood Pressure

University of Colorado, Denver · 118 planned · NCT04040959 · updated 2 Oct 2026

Phase 2Active, not recruitingGeroscience intervention

Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

Nicotinamide riboside in Hypertension, Aging

Douglas Seals · 118 planned · NCT03821623 · updated 2 Oct 2026

Phase 2CompletedAge-related condition

Study to Determine Optimal Dose and Evaluate Safety, Tolerability, and Pharmacokinetics of Progerinin in Patients With Hutchinson-Gilford Progeria Syndrome (HGPS)

Progerinin, Lonafarnib in Hutchinson-Gilford Progeria Syndrome

PRG Science & Technology Co., Ltd. · 10 enrolled · NCT06775041 · updated 2 Oct 2026

Phase 1RecruitingAge-related condition

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

18F-PF974, 18F-florbetaben in Alzheimer s Disease, Mild Cognitive Impairment, Healthy

National Institute of Mental Health (NIMH) · 90 planned · NCT07169630 · updated 2 Oct 2026

RecruitingGeroscience intervention

Autophagy-Enhancers to Reduce Sleep Disturbances (SpSleep)

Spermidine Supplementation in Mild Cognitive Impairment Due to Alzheimer's Disease, Subjective Cognitive Decline (SCD)

University Medicine Greifswald · 76 planned · NCT07383311 · updated 2 Oct 2026

Phase 1Not yet recruitingAge-related condition

Registered · 2 Oct 2026

[11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction (NEURO-HF)

[11C]PS13: [carbon-11]PS13; COX-1 PET radioligand, Sacubitril-Valsartan in Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild, Neuroinflammation

Stony Brook University · 18 planned · NCT07856043 · updated 2 Oct 2026

Phase 1Not yet recruitingAge-related condition

Registered · 2 Oct 2026

Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)

VinVital in Frailty Syndrome, Aging

Vinmec Research Institute of Stem Cell and Gene Technology · 20 planned · NCT07856602 · updated 2 Oct 2026

ObservationalRecruitingHealthspan endpoint

Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention (OPTIMA-C)

Stroke, Traumatic Brain Injury, Knee Osteoarthritis

Tan Tock Seng Hospital · 500 planned · NCT06073106 · updated 2 Oct 2026

Phase 4Active, not recruitingHealthspan endpoint

GLP-1s to Enhance Lasting Optimal Weight (GLOW)

Tirzepatide in Obesity

Wake Forest University Health Sciences · 40 enrolled · NCT06861439 · updated 2 Oct 2026

Not yet recruitingAge-related condition

Registered · 2 Oct 2026

The Improving Effects of French Maritime Pine Bark Extract on Antioxidation and Anti-inflammation a in Post-menopausal Women Based on Nutrigenomic Approach

French maritime pine bark extract in Gene Expression, Nutrigenomics

Taipei Medical University · 46 planned · NCT07855198 · updated 2 Oct 2026

ObservationalCompletedHealthspan endpoint

Registered · 2 Oct 2026

Biomarkers, Abdominal Muscle, and Frailty in CKD

total antioxidant status, total oxidant status, monocyte chemotactic protein-1 in Chronic Kidney Disease, Abdominal Muscles/Ultrasonography, Frailty

Ankara City Hospital Bilkent · 88 enrolled · NCT07854275 · updated 2 Oct 2026

CompletedAge-related condition

A Prolonged Nightly Fasting for Men on ADT for PCa

Prolonged Nightly Fasting (PNF+), Healthy Diet Text Messaging in Prostate Cancer

Thomas Jefferson University · 40 enrolled · NCT07462403 · updated 2 Oct 2026

Phase 3TerminatedAge-related condition

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation (HERMES)

Ziltivekimab in Heart Failure

Novo Nordisk A/S · 4,874 enrolled · NCT05636176 · updated 1 Oct 2026

Phase 3Active, not recruitingAge-related condition

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation (ATHENA)

Ziltivekimab in Heart Failure, Systemic Inflammation

Novo Nordisk A/S · 673 planned · NCT06200207 · updated 1 Oct 2026

Phase 1/2Not yet recruitingGeroscience intervention

Precision Microbiota Interventions for Senoreduction Trial (PreMIS)

Limosilactobacillus reuteri, Blueberry extract in HIV Infections, Alcohol Drinking, Aging

Louisiana State University Health Sciences Center in New Orleans · 160 planned · NCT07462767 · updated 1 Oct 2026

Early phase 1RecruitingGeroscience intervention

Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease (Senolytics)

Biospecimen Collection, Dasatinib, Fisetin in Glioma

Mayo Clinic · 30 planned · NCT07025226 · updated 1 Oct 2026

Not yet recruitingHealthspan endpoint

Registered · 1 Oct 2026

Functional Mobility and Resistance Exercise for Postmenopausal Females With Type 1 Diabetes (FLEX-T1D)

Resistance exercise in Type 1 Diabetes (T1D), Menopause

Institut de Recherches Cliniques de Montreal · 63 planned · NCT07851662 · updated 1 Oct 2026

Phase 4RecruitingAge-related condition

Precision Colchicine Intervention to Suppress Atherosclerosis in TET2 Clonal Hematopoiesis

Colchicine 0.5 mg orally once daily for 12 months., SoC therapy in Colchicine, Coronary Atherosclerosis Management, Clonal Hematopoiesis of Indeterminate Potential

Shenyang Northern Hospital · 120 planned · NCT07362966 · updated 1 Oct 2026

CompletedAge-related condition

Peanut Sip Feeding Protocol

Peanut protein in Protein Metabolism

Texas A&M University · 13 enrolled · NCT06693544 · updated 1 Oct 2026

CompletedGeroscience intervention

Impact of Time-Restricted Eating on Metabolic Homeostasis, Inflammation and Oxidative Stress in Metabolic Syndrome (TREMNIOS)

Time-Restricted Eating in Metabolic Syndrome, Overweight or Obesity, PreDiabetes

Nicolaus Copernicus University · 27 enrolled · NCT04328233 · updated 1 Oct 2026