The therapeutic potential of melatonin: Focus on the SIRT1 signaling pathway
ReviewMolecular biology reports
Topic
NAD+ & sirtuins
NAD+ precursors, sirtuins and the metabolism of aging cells.
YesterdayFri 2 OctFriday 2 October1 paper
Thu 1 Oct1 paper
CellsPreprint
AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1
Experiments in human cells and computational modeling show that fasting sensor AMPK requires NAD+ and PGC-1-alpha to modulate cellular circadian rhythms.
bioRxiv · Vandenberghe A et al.
Wed 30 Sep3 papers
Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells
CellsFrontiers in bioscience (Landmark edition)
Tue 29 Sep1 paper
AnimalsPeer-reviewed
Macrophage CD38 drives age-related placental senescence by depleting NAD+
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.
Nature communications · Hua L et al.