Pten knockout
Intervention1 paper1 finding
- Cells1
Outcomes
1Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
Pten knockout induces cellular senescence in mice.
Animalsprostate-specific conditional knockoutprostatemales
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling · Neoplasia (New York, N.Y.) · 1 Oct 2026
Latest
1CellsCellular senescence
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.